NDLI: Etravirine and Rilpivirine Drug Resistance Among HIV-1 Subtype C Infected Children Failing Non-Nucleoside Reverse Transcriptase Inhibitor-Based Regimens in South India.

Please wait, while we are loading the content...

Etravirine and Rilpivirine Drug Resistance Among HIV-1 Subtype C Infected Children Failing Non-Nucleoside Reverse Transcriptase Inhibitor-Based Regimens in South India.

Content Provider	Europe PMC
Author	Saravanan, Shanmugam Kausalya, Bagavathi Gomathi, Selvamurthi Sivamalar, Sathasivam Pachamuthu, Balakrishnan Selvamuthu, Poongulali Pradeep, Amrose Sunil, Solomon Mothi, Sarvode N. Smith, Davey M. kantor, Rami
Copyright Year	2017
Abstract	Abstract We have analyzed reverse transcriptase (RT) region of HIV-1 pol gene from 97 HIV-infected children who were identified as failing first-line therapy that included first-generation non-nucleoside RT inhibitors (Nevirapine and Efavirenz) for at least 6 months. We found that 54% and 65% of the children had genotypically predicted resistance to second-generation non-nucleoside RT inhibitors drugs Etravirine (ETR) and Rilpivirine, respectively. These cross-resistance mutations may compromise future NNRTI-based regimens, especially in resource-limited settings. To complement these investigations, we also analyzed the sequences in Stanford database, Monogram weighted score, and DUET weighted score algorithms for ETR susceptibility and found almost perfect agreement between the three algorithms in predicting ETR susceptibility from genotypic data.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5695734&blobtype=pdf
Page Count	8
ISSN	08892229
Volume Number	33
DOI	10.1089/aid.2016.0133
PubMed Central reference number	PMC5695734
Issue Number	6
PubMed reference number	27869478
Journal	AIDS Research and Human Retroviruses [AIDS Res Hum Retroviruses]
e-ISSN	19318405
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2016-12-23
Publisher Place	USA
Access Restriction	Open
Rights License	Copyright 2017, Mary Ann Liebert, Inc.
Subject Keyword	HIV drug resistance etravirine resistance in children HIV drug resistance in South India etravirine rilpivirine HIV in children subtype C resistance
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Virology Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in