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The role of 18F-fluorodeoxyglucose positron emission tomography in the assessment of disease activity of adult-onset Still's disease.
| Content Provider | Europe PMC |
|---|---|
| Author | An, Young-Sil Suh, Chang-Hee Jung, Ju-Yang Cho, Hundo Kim, Hyoun-Ah |
| Copyright Year | 2017 |
| Abstract | Background/Aims18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) has been suggested as a reliable imaging technique for monitoring of disease activity in patients with adult-onset Still’s disease (AOSD). Therefore, we investigated the clinical significance of 18F-FDG PET/CT in Korean AOSD patients.MethodsThirteen AOSD patients were included in the study. The PET/CT images were evaluated with visual and semiquantitative method using standardized uptake values (SUVs).ResultsThe presence of increased 18F-FDG uptake was noted in 90% of clinically active AOSD patients. 18F-FDG uptake was located in the lymph node, spleen, and bone marrow. Visual grade and SUV intensity of lymph node was significantly correlated with the systemic score of AOSD. Visual grade of spleen was significantly correlated with the systemic score, erythrocyte sedimentation rate (ESR), and ferritin. Additionally, visual grade and SUV intensity of bone marrow was significantly correlated with the systemic score, ESR, leukocyte, and neutrophil.ConclusionsVisual grade and SUV intensity of lymph node, spleen, and bone marrow on 18F-FDG PET/CT scan showed significant correlations with known disease activity markers. The data suggest that 18F-FDG PET/CT scan may be a useful imaging technique for evaluation of disease activity in AOSD patients. |
| ISSN | 12263303 |
| Volume Number | 32 |
| PubMed Central reference number | PMC5668387 |
| Issue Number | 6 |
| PubMed reference number | 27926812 |
| Journal | The Korean Journal of Internal Medicine [Korean J. Intern. Med] |
| e-ISSN | 20056648 |
| DOI | 10.3904/kjim.2015.322 |
| Language | English |
| Publisher | The Korean Association of Internal Medicine |
| Publisher Date | 2016-12-07 |
| Access Restriction | Open |
| Rights License | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2017 The Korean Association of Internal Medicine |
| Subject Keyword | Still’s disease, adult-onset 18F-fluorodeoxyglucose positron emission tomography/computed tomography Disease activity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Internal Medicine |
