Antitumor Vaccines Based on Dendritic Cells: From Experiments using Animal Tumor Models to Clinical Trials.

Content Provider	Europe PMC
Author	Markov, O. V. Mironova, N. L. Vlassov, V. V. Zenkova, M. A.
Copyright Year	2017
Abstract	The routine methods used to treat oncological diseases have a number ofdrawbacks, including non-specific action and severe side effects for patients.Furthermore, tumor diseases are associated with a suppression of the immunesystem that often leads to the inefficiency of standard treatment methods. Thedevelopment of novel immunotherapeutic approaches having specific antitumoraction and that activate the immune system is of crucial importance. Vaccinesbased on dendritic cells (DCs) loaded with tumor antigens ex vivothat can activate antitumor cytotoxic T-cell responses stand out amongdifferent antitumor immunotherapeutic approaches. This review is focused onanalyzing different methods of DC-based vaccine preparation and currentresearch in antitumor DC-based vaccines using animal tumor models and inclinical trials.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5662271&blobtype=pdf
ISSN	20758251
Journal	Acta Naturae
Volume Number	9
PubMed Central reference number	PMC5662271
Issue Number	3
PubMed reference number	29104773
Language	English
Publisher	A.I. Gordeyev
Publisher Date	2017-07-01
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of theCreative Commons Attribution License, which permits unrestricted use,distribution, and reproduction in any medium, provided the original work isproperly cited. Copyright ® 2017 Park-media Ltd.
Subject Keyword	dendritic cells antitumor vaccines delivery of tumor antigens murine tumor models clinical trials
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biochemistry Molecular Medicine Biotechnology