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Brain gray matter abnormalities in progressive supranuclear palsy revisited.
| Content Provider | Europe PMC |
|---|---|
| Author | Pan, PingLei Liu, Yi Zhang, Yang Zhao, Hui Ye, Xing Xu, Yun |
| Copyright Year | 2017 |
| Abstract | Whole-brain voxel-based morphometry (VBM) studies of progressive supranuclear palsy (PSP) have demonstrated heterogeneous findings regarding gray matter (GM) abnormalities. Here, we used Seed-based d Mapping, a coordinate-based meta-analytic approach to identify consistent regions of GM anomalies across studies of PSP. Totally, 18 original VBM studies, comprising 284 patients with PSP and 367 healthy controls were included. As compared to healthy controls, patients with PSP demonstrated significant GM reductions in both cortical and subcortical regions, including the frontal motor cortices, medial (including anterior cingulate cortex) and lateral frontal cortices, insula, superior temporal gyrus, striatum (putamen and caudate nucleus), thalamus, midbrain, and anterior cerebellum. Our study further suggests that many confounding factors, such as age, male ratio, motor severity, cognitive impairment severity, and illness duration of PSP patients, and scanner field-strength, could contribute to the heterogeneity of GM alterations in PSP across studies. Our comprehensive meta-analysis demonstrates a specific neuroanatomical pattern of GM atrophy in PSP with the involvement of the cortical-subcortical circuitries that mediate vertical supranuclear gaze palsy, motor disabilities (postural instability with falls and parkinsonism), and cognitive-behavioral disturbances. Confounding factors merit attention in future studies. |
| Journal | Oncotarget |
| Volume Number | 8 |
| PubMed Central reference number | PMC5655252 |
| Issue Number | 46 |
| PubMed reference number | 29113357 |
| e-ISSN | 19492553 |
| DOI | 10.18632/oncotarget.20895 |
| Language | English |
| Publisher | Impact Journals LLC |
| Publisher Date | 2017-09-15 |
| Access Restriction | Open |
| Rights License | This article is distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. Copyright: © 2017 Pan et al. |
| Subject Keyword | progressive supranuclear palsy voxel-based morphometry meta-analysis cortical-subcortical circuitries seed-based d mapping |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oncology |
