NDLI: Statin use and non-melanoma skin cancer risk: a meta-analysis of randomized controlled trials and observational studies.

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Statin use and non-melanoma skin cancer risk: a meta-analysis of randomized controlled trials and observational studies.

Content Provider	Europe PMC
Author	Yang, Keming Marley, Andrew Tang, Huilin Song, Yiqing Tang, Jean Y. Han, Jiali
Copyright Year	2017
Abstract	BackgroundExisting evidence of the association between statin use and non-melanoma skin cancer (NMSC) risk has been inconsistent.ObjectiveTo maximize statistical power to synthesize prospective evidence on this relationship.Materials and MethodsPubMed, EMBASE, Web of Science, Cochrane Central Register of Controlled Trials, and ClinicalTrial.gov were systematically searched up to December 11, 2016. A random-effects meta-analysis was conducted to calculate summary estimates.ResultsOur meta-analysis of 14 randomized controlled trials (RCTs) including 63,157 subjects showed no significant association between statin use and NMSC risk (RR = 1.09, 95%CI = 0.85–1.39). However, meta-analysis of four observational studies including 1,528,215 participants showed significantly increased risk of NMSC among statin users compared to non-users (RR = 1.11, 95%CI = 1.02–1.22). Furthermore, ever using lipophilic statins (RR = 1.14, 95%CI = 1.04–1.24) or lower-potency statins (RR = 1.14, 95%CI = 1.03–1.26), as well as usage of any statin longer than one year (RR = 1.14, 95%CI = 1.09–1.18) were significantly associated with increased NMSC risk based on observational studies.ConclusionsEvidence from observational studies supported an association between statin use and increased NMSC risk. This finding should be interpreted with caution due to modest number of included studies, possible between-study heterogeneity and inherent limitations of observational studies.
Journal	Oncotarget
Volume Number	8
PubMed Central reference number	PMC5650431
Issue Number	43
PubMed reference number	29088876
e-ISSN	19492553
DOI	10.18632/oncotarget.20034
Language	English
Publisher	Impact Journals LLC
Publisher Date	2017-08-08
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright: © 2017 Yang et al.
Subject Keyword	statins non-melanoma skin cancer meta-analysis
Content Type	Text
Resource Type	Article
Subject	Oncology

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