NDLI: RAS testing and cetuximab treatment for metastatic colorectal cancer: a cost-effectiveness analysis in a setting with limited health resources.

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RAS testing and cetuximab treatment for metastatic colorectal cancer: a cost-effectiveness analysis in a setting with limited health resources.

Content Provider	Europe PMC
Author	Wu, Bin Yao, Yuan Zhang, Ke Ma, Xuezhen
Copyright Year	2017
Abstract	PURPOSETo test the cost-effectiveness of cetuximab plus irinotecan, fluorouracil, and leucovorin (FOLFIRI) as first-line treatment in patients with metastatic colorectal cancer (mCRC) from a Chinese medical insurance perspective.RESULTSBaseline analysis showed that the addition of cetuximab increased quality-adjusted life-years (QALYs) by 0.63, an increase of $17,086 relative to FOLFIRI chemotherapy, resulting in an incremental cost-effectiveness ratio (ICER) of $27,145/QALY. When the patient assistance program (PAP) was available, the ICER decreased to $14,049/QALY, which indicated that the cetuximab is cost-effective at a willingness-to-pay threshold of China ($22,200/QALY). One-way sensitivity analyses showed that the median overall survival time for the cetuximab was the most influential parameter.METHODSA Markov model by incorporating clinical, utility and cost data was developed to evaluate the economic outcome of cetuximab in mCRC. The lifetime horizon was used, and sensitivity analyses were carried out to test the robustness of the model results. The impact of PAP was also evaluated in scenario analyses.CONCLUSIONSRAS testing with cetuximab treatment is likely to be cost-effective for patients with mCRC when PAP is available in China.
Journal	Oncotarget
Volume Number	8
PubMed Central reference number	PMC5642627
Issue Number	41
PubMed reference number	29050352
e-ISSN	19492553
DOI	10.18632/oncotarget.17029
Language	English
Publisher	Impact Journals LLC
Publisher Date	2017-04-11
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright: © 2017 Wu et al.
Subject Keyword	colorectal cancer cost-effectiveness cetuximab gene mutation
Content Type	Text
Resource Type	Article
Subject	Oncology

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