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The Impact of Lymphovascular Space Invasion on Recurrence and Survival in Iranian Patients With Early Stage Endometrial Cancer.
| Content Provider | Europe PMC |
|---|---|
| Author | Akhavan, Setareh Ahmadzadeh, Azar Mousavi, Azamsadat Gilany, Mitra Modares Kazemi, Zohreh Rahim, Fakher Shirali, Elham |
| Copyright Year | 2016 |
| Abstract | BackgroundThe aim of this study was to assess the impact of lymphovascular space involvement (LVSI) on recurrence and survival in early stage of endometrial cancer (EC).MethodsPatients with EC referred to Imam Khomeini Hospital in Tehran were examined and enrolled over a 10-year period (2004 - 2015). The effect of LVSI on recurrence and overall survival was analyzed using the Kaplan-Meier and log-rank test methods.ResultsA total of 160 patients with early stage EC were identified. Out of 160 women with EC, 135 (84.4%) underwent primary surgery. One hundred and twenty-one (76.2%) patients were not found to have LVSI, whereas 38 (23.8%) were found to have LVSI. Of the 38 patients with LVSI, 21 (55.3%) had endometrioid cell type tumor, 10 (26.3%) had serous, one (2.6%) had clear cell and six (15.8%) had adeno-squamous cell type tumor.ConclusionThe presence of LVSI represents a factor strongly associated with high risk of recurrence and poor survival in early stage EC. Patients with lower International Federation of Obstetrics and Gynecology (FIGO) stages may be at increased risk of recurrence and a poor overall survival if the pathological findings confirm the presence of LVSI. Thus, LVSI should be added to the traditional factors used to decide whether patients with early stage EC are at high risk of recurrence and adjuvant therapy planning. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5624702&blobtype=pdf |
| ISSN | 19204531 |
| Journal | World Journal of Oncology [World J Oncol] |
| Volume Number | 7 |
| DOI | 10.14740/wjon981w |
| PubMed Central reference number | PMC5624702 |
| Issue Number | 4 |
| PubMed reference number | 28983367 |
| e-ISSN | 1920454X |
| Language | English |
| Publisher | Elmer Press |
| Publisher Date | 2016-08-01 |
| Access Restriction | Open |
| Rights License | This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright 2016, Akhavan et al. |
| Subject Keyword | Lymphovascular space invasion Prognostic factors Endometrial cancer Early stage endometrial cancer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
