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Magnesium-based biodegradable alloys: Degradation, application, and alloying elements.
| Content Provider | Europe PMC |
|---|---|
| Author | Pogorielov, Maksym Husak, Eugenia Solodivnik, Alexandr Zhdanov, Sergii |
| Copyright Year | 2017 |
| Abstract | In recent years, the paradigm about the metal with improved corrosion resistance for application in surgery and orthopedy was broken. The new class of biodegradable metal emerges as an alternative for biomedical implants. These metals corrode gradually with an appropriate host response and release of corrosion products. And it is absolutely necessary to use essential metals metabolized by hosting organism with local and general nontoxic effect. Magnesium serves this aim best; it plays the essential role in body metabolism and should be completely excreted within a few days after degradation. This review summarizes data from Mg discovery and its first experimental and clinical application of modern concept of Mg alloy development. We focused on biodegradable metal application in general surgery and orthopedic practice and showed the advantages and disadvantages Mg alloys offer. We focused on methods of in vitro and in vivo investigation of degradable Mg alloys and correlation between these methods. Based on the observed data, a better way for new alloy pre-clinical investigation is suggested. This review analyzes possible alloying elements that improve corrosion rate, mechanical properties, and gives the appropriate host response. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5598119&blobtype=pdf |
| Page Count | 12 |
| ISSN | 20611617 |
| Volume Number | 9 |
| DOI | 10.1556/1646.9.2017.1.04 |
| PubMed Central reference number | PMC5598119 |
| Issue Number | 1 |
| PubMed reference number | 28932493 |
| Journal | Interventional Medicine & Applied Science [Interv Med Appl Sci] |
| e-ISSN | 20615094 |
| Language | English |
| Publisher | Akadémiai Kiadó |
| Publisher Date | 2017-03-01 |
| Publisher Place | Budapest |
| Access Restriction | Open |
| Rights License | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium for non-commercial purposes, provided the original author and source are credited. © 2017 The Author(s) |
| Subject Keyword | biodegradable metals magnesium corrosion surgery orthopedy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
