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Beyond a Gasotransmitter: Hydrogen Sulfide and Polysulfide in Cardiovascular Health and Immune Response.
| Content Provider | Europe PMC |
|---|---|
| Author | Yuan, Shuai Shen, Xinggui Kevil, Christopher G. |
| Copyright Year | 2017 |
| Abstract | Abstract Significance: Hydrogen sulfide (H2S) metabolism leads to the formation of oxidized sulfide species, including polysulfide, persulfide, and others. Evidence is emerging that many biological effects of H2S may indeed be due to polysulfide and persulfide activation of signaling pathways and reactivity with discrete small molecules. Recent Advances: Exogenous oxidized sulfide species, including polysulfides, are more reactive than H2S with a wide range of molecules. Importantly, endogenous polysulfide and persulfide formation has been reported to occur via transsulfuration enzymes, cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS). Critical Issues: In light of the recent understanding of oxidized sulfide metabolite formation and reactivity, comparatively few studies have been reported comparing cellular biological and in vivo effects of H2S donors versus polysulfide and persulfide donors. Likewise, it is equally unclear when, how, and to what extent persulfide and polysulfide formation occurs in vivo under pathophysiological conditions. Future Directions: Additional studies regarding persulfide and polysulfide formation and molecular reactions are needed in nearly all aspects of biology to better understand how sulfide metabolites contribute to key chemical biology reactions involved in cardiovascular health and immune responses. Antioxid. Redox Signal. 27, 634–653. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5576200&blobtype=pdf |
| Page Count | 20 |
| ISSN | 15230864 |
| Volume Number | 27 |
| DOI | 10.1089/ars.2017.7096 |
| PubMed Central reference number | PMC5576200 |
| Issue Number | 10 |
| PubMed reference number | 28398086 |
| Journal | Antioxidants & Redox Signaling [Antioxid Redox Signal] |
| e-ISSN | 15577716 |
| Language | English |
| Publisher | Mary Ann Liebert, Inc. |
| Publisher Date | 2017-06-01 |
| Publisher Place | USA |
| Access Restriction | Open |
| Rights License | Copyright 2017, Mary Ann Liebert, Inc. |
| Subject Keyword | gasotransmitter persulfide polysulfide sulfide thiol |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Physiology Medicine Clinical Biochemistry Molecular Biology Biochemistry |
