NDLI: Kaempferol Alleviates the Interleukin-1β-Induced Inflammation in Rat Osteoarthritis Chondrocytes via Suppression of NF-κB.

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Kaempferol Alleviates the Interleukin-1β-Induced Inflammation in Rat Osteoarthritis Chondrocytes via Suppression of NF-κB.

Content Provider	Europe PMC
Author	Zhuang, Zhengling Ye, Guangqun Huang, Bin
Copyright Year	2017
Abstract	BackgroundThis study was designed to examine the anti-inflammatory and anti-osteoarthritis (OA) effects of kaempferol in rat articular chondrocytes stimulated with interleukin-1β.Material/MethodsRat articular chondrocytes cultures were treated with interleukin-1β alone or with kaempferol (25, 50, 100, and 200 μM) and interleukin-1β. The effect of kaempferol on chondrocyte cells viability was measured by MTT assay. The effect on prostaglandin E2 (PGE2) and nitric oxide (NO) level were also assessed using the ELISA and Griess reagent, respectively, for kaempferol activity. Moreover, the expression of iNOS, Cox-2 and activation of NF-κB under influence of kaempferol was also assessed by Western blot.ResultsKaempferol treatment (up to 100 μM) in a concentration-dependent way caused reduction in the interleukin-1β-stimulated formations of PGE2 and NO. Kaempferol also upregulated the expression of iNOS and Cox-2 in interleukin-1β-stimulated rat OA chondrocytes. Additionally, kaempferol was found to inhibit the IκBα degradation and NF-κB activation in rat chondrocytes stimulated with interleukin-1β.ConclusionsKaempferol significantly caused reduction in interleukin-1β-stimulated pro-inflammatory mediators in rat OA chondrocytes by inhibiting the NF-κB pathway. These results suggest that kaempferol had significant anti-inflammatory and anti-arthritis effects. Thus, kaempferol, as a novel therapeutic active agent, may prevent, stop, or retard the progression of OA.
ISSN	12341010
Journal	Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Volume Number	23
PubMed Central reference number	PMC5566200
PubMed reference number	28806392
e-ISSN	16433750
DOI	10.12659/msm.902491
Language	English
Publisher	International Scientific Literature, Inc.
Publisher Date	2017-08-14
Access Restriction	Open
Rights License	This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) © Med Sci Monit, 2017
Subject Keyword	Inflammation Interleukin-1beta Osteoarthritis
Content Type	Text
Resource Type	Article
Subject	Medicine

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