NDLI: Renal denervation attenuates cardiac hypertrophy in spontaneously hypertensive rats via regulation of autophagy.

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Renal denervation attenuates cardiac hypertrophy in spontaneously hypertensive rats via regulation of autophagy.

Content Provider	Europe PMC
Author	Huang, Jionghua Huang, He Pan, Wei Ou, Dejin Dai, Wenjun Lin, Yuhui Wu, Jinlei Xie, Wenjie Chen, Ximing
Copyright Year	2017
Abstract	It has been suggested that renal denervation (RD) may attenuate left ventricular (LV) hypertrophy. However, the role that autophagy serves in this process is currently unclear. In the present study, utilizing a model of hypertension-induced cardiac hypertrophy in spontaneous hypertensive rats, it was demonstrated that RD was significantly associated with a reduction in LV hypertrophy. Furthermore, a decrease in the myocardial mRNA of hypertrophy-associated genes was demonstrated in RD rats compared with sham controls. In addition, RD in hypertension-induced LV hypertrophy rats was associated with the attenuation of cellular autophagic response over activation at a physiological level. This was indicated by a reduction in the expression of Beclin-1, autophagy related 9A and microtubule-associated protein 1A/1B-light chain 3 II/I in RD rats to physiological levels that are observed in control rats. Furthermore, the number of autophagosomes was restored to physiological levels in the cardiomyocytes of RD rats. The results of the current study suggest that RD may attenuate LV hypertrophy via the regulation of autophagic responses.
ISSN	17912997
Journal	Molecular Medicine Reports
Volume Number	16
PubMed Central reference number	PMC5562017
Issue Number	2
PubMed reference number	28627693
e-ISSN	17913004
DOI	10.3892/mmr.2017.6790
Language	English
Publisher	D.A. Spandidos
Publisher Date	2017-06-15
Access Restriction	Open
Rights License	This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Copyright: © Huang et al.
Subject Keyword	cardiac autophagy renal denervation left ventricular hypertrophy spontaneously hypertensive rats
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Biochemistry Cancer Research Molecular Medicine Oncology

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