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Dual-negative expression of Nrf2 and NQO1 predicts superior outcomes in patients with non-small cell lung cancer.
| Content Provider | Europe PMC |
|---|---|
| Author | Tong, Ying-Hui Zhang, Bo Yan, You-You Fan, Yun Yu, Jia-Wen Kong, Si-Si Zhang, Dan Fang, Luo Su, Dan Lin, Neng-Ming |
| Copyright Year | 2017 |
| Abstract | Functional studies in non-small cell lung cancer (NSCLC) patients revealed that hyperactivation of the NF-E2-related factor 2 (Nrf2) pathway facilitates tumor growth. We examined the usefulness of Nrf2 and NQO1 as indicators of prognosis in NSCLC. Tumor and adjacent non-tumor tissue samples were collected from 215 NSCLC patients who had tumor resections between 2006 and 2011. Immunohistochemistry was performed to detect Nrf2 or NQO1 expression. The correlation between Nrf2 or NQO1 expression and survival outcomes was evaluated using the Kaplan-Meier method and Cox proportional hazards regression model. Levels of Nrf2 and NQO1 were elevated in tumor tissues. In particular, Nrf2 was elevated in nearly all tumor cells. NQO1 expression positively correlated with Nrf2 expression (P = 0.039). Nrf2 expression positively correlated with lymph node metastasis (P = 0.001) and negatively correlated with tumor differentiation (P = 0.032). As compared with either Nrf2 or NQO1 alone, dual-negative expression of Nrf2 and NQO1 was more predictive of superior overall survival (P = 0.020) and disease free survival (P = 0.037). Subgroup analyses showed that females, nonsmokers, and patients with advanced-stage NSCLC were suitable populations in which to evaluate prognosis based on Nrf2 and NQO1 co-expression. These results indicate that dual-negative expression of Nrf2 and NQO1 is predictive of a better prognosis in NSCLC patients. |
| Journal | Oncotarget |
| Volume Number | 8 |
| PubMed Central reference number | PMC5542223 |
| Issue Number | 28 |
| PubMed reference number | 28501854 |
| e-ISSN | 19492553 |
| DOI | 10.18632/oncotarget.17403 |
| Language | English |
| Publisher | Impact Journals LLC |
| Publisher Date | 2017-07-01 |
| Access Restriction | Open |
| Rights License | This article is distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. Copyright: © 2017 Tong et al. |
| Subject Keyword | non-small cell lung cancer (NSCLC) NF-E2-related factor 2 (Nrf2) NAD(P)H quinone oxidoreductase-1 (NQO1) prognosis dual-negative expression |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oncology |
