NDLI: Full Genome Characterization of a New Simian Immune Deficiency Virus Lineage in a Naturally Infected Cercopithecus ascanius whitesidei in the Democratic Republic of Congo Reveals High Genetic Diversity Among Red-Tailed Monkeys in Central and Eastern Africa.

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Full Genome Characterization of a New Simian Immune Deficiency Virus Lineage in a Naturally Infected Cercopithecus ascanius whitesidei in the Democratic Republic of Congo Reveals High Genetic Diversity Among Red-Tailed Monkeys in Central and Eastern Africa.

Content Provider	Europe PMC
Author	Ahuka-Mundeke, Steve Mbala-Kingebeni, Placide Ndimbo-Kumogo, Simon-Pierre Foncelle, Caroline Lunguya-Metila, Octavie Muyembe-Tamfum, Jean-Jacques Delaporte, Eric Peeters, Martine Ayouba, Ahidjo
Copyright Year	2017
Abstract	Abstract Our knowledge on simian immune deficiency virus (SIV) diversity and evolution in the different nonhuman primate species is still incomplete. In this study, we report the full genome characterization of a new SIV from a red-tailed monkey (2013DRC-I8), from the Cercopithecus ascanius whitesidei subspecies, in the Democratic Republic of Congo (DRC). The new full-length genome is 9,926 bp long, and the genomic structure is similar to that of other SIVs with the absence of vpx and vpu genes. The new SIVasc-13DRC-I8 strain fell within the Cercopithecus specific SIV lineage. SIVasc-13DRC-I8 and previously reported SIVrtg from the C.a. schmidti subspecies in Uganda did not form a separate species-specific SIV lineage. These observations provide additional evidence for high genetic diversity and the complex evolution of SIVs in the Cercopithecus genus. More studies on a large number of monkeys from a wider geographic area are needed to understand SIV evolution.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5512325&blobtype=pdf
Page Count	5
ISSN	08892229
Volume Number	33
DOI	10.1089/aid.2017.0027
PubMed Central reference number	PMC5512325
Issue Number	7
PubMed reference number	28383997
Journal	AIDS Research and Human Retroviruses [AIDS Res Hum Retroviruses]
e-ISSN	19318405
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2017-04-06
Publisher Place	USA
Access Restriction	Open
Rights License	Copyright 2017, Mary Ann Liebert, Inc.
Subject Keyword	SIV HIV Cercopithecus ascanius red-tailed monkey Democratic Republic of Congo
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Virology Immunology

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