Multi-parametric study of temperature and thermal damage of tumor exposed to high-frequency nanosecond-pulsed electric fields based on finite element simulation.

Content Provider	Europe PMC
Author	Mi, Yan Rui, Shaoqin Li, Chengxiang Yao, Chenguo Xu, Jin Bian, Changhao Tang, Xuefeng
Abstract	High-frequency nanosecond-pulsed electric fields were recently introduced for tumor or abnormal tissue ablation to solve some problems of conventional electroporation. However, it is necessary to study the thermal effects of high-field-intensity nanosecond pulses inside tissues. The multi-parametric analysis performed here is based on a finite element model of liver tissue with a tumor that has been punctured by a pair of needle electrodes. The pulse voltage used in this study ranges from 1 to 4 kV, the pulse width ranges from 50 to 500 ns, and the repetition frequency is between 100 kHz and 1 MHz. The total pulse length is 100 μs, and the pulse burst repetition frequency is 1 Hz. Blood flow and metabolic heat generation have also been considered. Results indicate that the maximum instantaneous temperature at 100 µs can reach 49 °C, with a maximum instantaneous temperature at 1 s of 40 °C, and will not cause thermal damage during single pulse bursts. By parameter fitting, we can obtain maximum instantaneous temperature at 100 µs and 1 s for any parameter values. However, higher temperatures will be achieved and may cause thermal damage when multiple pulse bursts are applied. These results provide theoretical basis of pulse parameter selection for future experimental researches.
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ISSN	01400118
Journal	Medical & Biological Engineering & Computing [Med Biol Eng Comput]
Volume Number	55
DOI	10.1007/s11517-016-1589-3
PubMed Central reference number	PMC5486631
Issue Number	7
PubMed reference number	27853990
e-ISSN	17410444
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-11-16
Publisher Place	Berlin/Heidelberg
Access Restriction	Open
Rights License	Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. © The Author(s) 2016
Subject Keyword	Multi-parameters Temperature Thermal damage Tumor High-frequency nanosecond-pulsed electric fields Finite element method
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering Computer Science Applications