Corifollitropin alfa compared to daily rFSH or HP-HMG in GnRH antagonist controlled ovarian stimulation protocol for patients undergoing assisted reproduction.

Content Provider	Europe PMC
Author	Souza, Priscila Morais Galvão de Carvalho, Bruno Ramalho Nakagawa, Hitomi Miura Rassi, Thalita Reis Esselin Barbosa, Antônio César Paes Silva, Adelino Amaral
Abstract	ObjectiveThis study aimed to compare the outcomes of controlled ovarian stimulation(COS) with corifollitropin alfa versus daily recombinantfollicle-stimulating hormone (rRFSH) or highly purified human menopausalgonadotropin (HP-HMG) in patients undergoing in vitro fertilization (IVF) cycles based on gonadotropin-releasing hormone (GnRH)antagonist protocols. The primary endpoints were total number of oocytes andmature oocytes.MethodsThis retrospective study looked into 132 controlled ovarian stimulationcycles from IVF or oocyte cryopreservation performed in a private humanreproduction center between January 1 and December 31, 2014. Enrollmentcriteria: women aged < 40 years submitted to COS with corifollitropinalfa 100µg or 150µg (n = 26) and rFSH or HP-HMG in the firstseven days of treatment with daily doses of 150-225 IU (n = 106); allsubjects were on GnRH antagonist protocols.ResultsThe groups had similar mean ages and duration of stimulation. The mean number± standard deviation of total aspirated oocytes and MII oocytes was11.9±10 and 10.3±7.9 in the corifollitropin alfa group, and10.9±7.2 and 8.6±5.7 in the group on rFSH or HMG(p>0.05). There were no significant differences infertilization (76.9% vs. 76.8%, p=1.0), biochemicalpregnancy (66.7% vs. 47.2%, p=0.1561) or embryoimplantation rates (68.7% vs. 50%, p=0.2588) between thegroups using corifollitropin alfa and rFSH or HMG, respectively.ConclusionsCorifollitropin alfa seems to be as effective as rFSH or HP-HMG when used inthe first seven days of ovulation induction for patients undergoing assistedreproduction in GnRH antagonist protocols.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5473695&blobtype=pdf
ISSN	15175693
Journal	JBRA Assisted Reproduction [JBRA Assist Reprod]
Volume Number	21
DOI	10.5935/1518-0557.20170017
PubMed Central reference number	PMC5473695
Issue Number	2
PubMed reference number	28609269
e-ISSN	15180557
Language	English
Publisher	Brazilian Society of Assisted Reproduction
Publisher Date	2017-06-01
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of theCreative Commons Attribution License, which permits unrestricted use,distribution, and reproduction in any medium, provided the original work isproperly cited.
Subject Keyword	Corifollitropin alfa gonadotropins ovulation induction in vitro fertilization assisted reproductive technology
Content Type	Text
Resource Type	Article
Subject	Obstetrics and Gynecology