NDLI: Common Genetic Variant of insig2 Gene rs7566605 Polymorphism Is Associated with Severe Obesity in North India

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Common Genetic Variant of insig2 Gene rs7566605 Polymorphism Is Associated with Severe Obesity in North India

Content Provider	Europe PMC
Author	Prakash, Jai Mittal, Balraj Srivastava, Apurva Awasthi, Shally Srivastava, Pranjal Srivastava, Neena
Copyright Year	2017
Abstract	Background:Obesity is a very common disorder resulting from an imbalance between food intake and energy expenditure, and it has a substantial impact on the development of chronic diseases. The aim of this study was to examine the association of INSIG2 (rs7566605) gene polymorphism with obesity and obesity associated phenotypes in North Indian subjects.Methods:The variants were investigated for association in 642 obese and non-obese individuals. The genotyping of INSIG2 (rs7566605) single nucleotide polymorphism was analyzed by the TaqMan allelic discrimination protocol.Results:A significant association was observed for INSIG2 (rs7566605) single nucleotide polymorphism with obesity and obesity-related phenotypes. Furthermore, a significant relationship was found between the rs7566605 and insulin, homeostasis model of assessment-insulin resistance, the percentage of body fat, fat mass, leptin, and adiponectin.Conclusion:The present study observed significant association between INSIG2 (rs7566605) single nucleotide polymorphism and obesity, as well as obesity-associated phenotypes in North Indian population.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5459941&blobtype=pdf
ISSN	1028852X
Journal	Iranian Biomedical Journal [Iran Biomed J]
Volume Number	21
DOI	10.18869/acadpub.ibj.21.4.261
PubMed Central reference number	PMC5459941
Issue Number	4
PubMed reference number	28160769
e-ISSN	2008823X
Language	English
Publisher	Pasteur Institute
Publisher Date	2017-05-21
Publisher Place	Iran
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright: © Iranian Biomedical Journal
Subject Keyword	INSIG2 Body mass index Insulin Insulin resistance Polymorphism
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Clinical Biochemistry Biochemistry, Genetics and Molecular Biology

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