Distinguishing Bipolar Depression from Unipolar Depression in Youth: Preliminary Findings.

Content Provider	Europe PMC
Author	Diler, Rasim Somer Goldstein, Tina R. Hafeman, Danella Merranko, John Liao, Fangzi Goldstein, Benjamin I. Hower, Heather Gill, Mary Kay Hunt, Jeffrey Yen, Shirley Keller, Martin B. Axelson, David Strober, Michael Iyengar, Satish Ryan, Neal D. Birmaher, Boris
Copyright Year	2017
Abstract	Abstract Objectives: To identify mood symptoms that distinguishes bipolar disorder (BP) depression versus unipolar depression in youth during an acute depressive episode. Methods: Youth with BP (N = 30) were compared with youth with unipolar depression (N = 59) during an acute depressive episode using the depression and mania items derived from the Schedule for Affective Disorders and Schizophrenia for Children (K-SADS)-Present Version. The results were adjusted for multiple comparisons, and any significant between-group differences in demographic, nonmood comorbid disorders, and psychiatric family history. Results: In comparison with unipolar depressed youth, BP depressed youth had significantly higher scores in several depressive symptoms and all subsyndromal manic symptoms, with the exception of increased goal-directed activity. Among the depressive symptoms, higher ratings of nonsuicidal physical self-injurious acts and mood reactivity, and lower ratings of aches/pains, were the symptoms that best discriminated BP from unipolar depressed youth. Subsyndromal manic symptoms, particularly motor hyperactivity, distractibility, and pressured speech, were higher in BP depressed youth and discriminated BP depressed from unipolar depressed youth. Conclusions: The results of this study suggest that it is possible to differentiate BP depression from unipolar depression based on depressive symptoms, and in particular subsyndromal manic symptoms. If replicated, these results have important clinical and research implications.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5439419&blobtype=pdf
Page Count	10
ISSN	10445463
Volume Number	27
DOI	10.1089/cap.2016.0154
PubMed Central reference number	PMC5439419
Issue Number	4
PubMed reference number	28398819
Journal	Journal of Child and Adolescent Psychopharmacology [J Child Adolesc Psychopharmacol]
e-ISSN	15578992
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2017-02-28
Publisher Place	USA
Access Restriction	Open
Rights License	Copyright 2017, Mary Ann Liebert, Inc.
Subject Keyword	depression bipolar atypical depressive symptoms manic symptoms mixed features
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical) Psychiatry and Mental Health Pediatrics, Perinatology and Child Health