The Effect of Rhus verniciflua Stokes Extracts on Photo-Aged Mouse Skin.

Content Provider	Europe PMC
Author	Hong, Hannah Jung, Minyoung Choe, Sung Jay Kim, Jung-Bae Choi, Eung Ho
Copyright Year	2017
Abstract	BackgroundRhus verniciflua Stokes (RV) has traditionally been used in Korea as an indigenous food (Rhus chicken soup) and as an herbal medicinal plant. While the anticancer, antimicrobial, and anti-inflammatory properties of RV have been actively studied in the medical field, its antioxidant effects in the skin that resist the reactive oxygen species in keratinocytes and fibroblasts is less understood.ObjectiveWe designed to evaluate the effects of R. verniciflua Stokes extract (RVE) on the photo-aged skin by an in vitro experiment using human fibroblasts and an in vivo experiment using a photo-aged murine model.MethodsFor the in vitro experiments, human fibroblasts irradiated with ultraviolet (UV) B were treated with RVE or vehicle, and the growth levels and the expression level of type 1 procollagen were compared. For the in vivo experiment, photo-aged mice irradiated with UVB and UVA were administered drinking water with or without RVE, and histological changes and the expression level of type 1 procollagen and matrix metalloprotease (MMP)-13 were compared.ResultsIn vitro experiments using fibroblasts irradiated with UVB showed that RVE promoted growth and significantly increased the expression of type 1 procollagen as compared to the control group. In the photo-aged mice, RVE increased collagen content in the dermis and promoted the synthesis of type 1 procollagen without any visible decrease in MMP-13 as compared to control group.ConclusionIn addition to the previously reported antioxidant effects of RVE, oral intake of RVE effectively inhibited photo-aging in hairless mice by enhancing collagen synthesis.
ISSN	10139087
Journal	Annals of Dermatology
Volume Number	29
PubMed Central reference number	PMC5438935
Issue Number	3
PubMed reference number	28566905
e-ISSN	20053894
DOI	10.5021/ad.2017.29.3.295
Language	English
Publisher	The Korean Dermatological Association; The Korean Society for Investigative Dermatology
Publisher Date	2017-05-11
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2017 The Korean Dermatological Association and The Korean Society for Investigative Dermatology
Subject Keyword	Aging Antioxidant Collagen Fibroblasts Rhus
Content Type	Text
Resource Type	Article
Subject	Dermatology