NDLI: Translational control of mRNAs by 3'-Untranslated region binding proteins.

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Translational control of mRNAs by 3'-Untranslated region binding proteins.

Content Provider	Europe PMC
Author	Yamashita, Akio Takeuchi, Osamu
Copyright Year	2017
Abstract	Eukaryotic gene expression is precisely regulated at all points between transcription and translation. In this review, we focus on translational control mediated by the 3′-untranslated regions (UTRs) of mRNAs. mRNA 3′-UTRs contain cis-acting elements that function in the regulation of protein translation or mRNA decay. Each RNA binding protein that binds to these cis-acting elements regulates mRNA translation via various mechanisms targeting the mRNA cap structure, the eukaryotic initiation factor 4E (eIF4E)-eIF4G complex, ribosomes, and the poly (A) tail. We also discuss translation-mediated regulation of mRNA fate.
ISSN	19766696
Journal	BMB Reports
Volume Number	50
PubMed Central reference number	PMC5437963
Issue Number	4
PubMed reference number	28287067
e-ISSN	1976670X
DOI	10.5483/BMBRep.2017.50.4.040
Language	English
Publisher	Korean Society for Biochemistry and Molecular Biology
Publisher Date	2017-04-01
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2017 by the The Korean Society for Biochemistry and Molecular Biology
Subject Keyword	RNA binding protein Translation Translation initiation 3′-UTR
Content Type	Text
Resource Type	Article
Subject	Medicine Molecular Biology Biochemistry

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