NDLI: Nonsense-mediated mRNA decay at the crossroads of many cellular pathways.

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Nonsense-mediated mRNA decay at the crossroads of many cellular pathways.

Content Provider	Europe PMC
Author	Lejeune, Fabrice
Copyright Year	2017
Abstract	Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism ensuring the fast decay of mRNAs harboring a premature termination codon (PTC). As a quality control mechanism, NMD distinguishes PTCs from normal termination codons in order to degrade PTC-carrying mRNAs only. For this, NMD is connected to various other cell processes which regulate or activate it under specific cell conditions or in response to mutations, mis-regulations, stresses, or particular cell programs. These cell processes and their connections with NMD are the focus of this review, which aims both to illustrate the complexity of the NMD mechanism and its regulation and to highlight the cellular consequences of NMD inhibition.
ISSN	19766696
Journal	BMB Reports
Volume Number	50
PubMed Central reference number	PMC5437961
Issue Number	4
PubMed reference number	28115040
e-ISSN	1976670X
DOI	10.5483/BMBRep.2017.50.4.015
Language	English
Publisher	Korean Society for Biochemistry and Molecular Biology
Publisher Date	2017-04-01
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2017 by the The Korean Society for Biochemistry and Molecular Biology
Subject Keyword	Cellular pathway Nonsense mutations Nonsense-mediated mRNA decay (NMD) Quality control mechanism UPF proteins
Content Type	Text
Resource Type	Article
Subject	Medicine Molecular Biology Biochemistry

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