Recent developments in the nanostructured materials functionalized with ruthenium complexes for targeted drug delivery to tumors.

Content Provider	Europe PMC
Author	Thangavel, Prakash Viswanath, Buddolla Kim, Sanghyo
Copyright Year	2017
Abstract	In recent years, the field of metal-based drugs has been dominated by other existing precious metal drugs, and many researchers have focused their attention on the synthesis of various ruthenium (Ru) complexes due to their potential medical and pharmaceutical applications. The beneficial properties of Ru, which make it a highly promising therapeutic agent, include its variable oxidation states, low toxicity, high selectivity for diseased cells, ligand exchange properties, and the ability to mimic iron binding to biomolecules. In addition, Ru complexes have favorable adsorption properties, along with excellent photochemical and photophysical properties, which make them promising tools for photodynamic therapy. At present, nanostructured materials functionalized with Ru complexes have become an efficient way to administer Ru-based anticancer drugs for cancer treatment. In this review, the recent developments in the nanostructured materials functionalized with Ru complexes for targeted drug delivery to tumors are discussed. In addition, information on “traditional” (ie, non-nanostructured) Ru-based cancer therapies is included in a precise manner.
ISSN	11769114
Journal	International Journal of Nanomedicine
Volume Number	12
PubMed Central reference number	PMC5388259
PubMed reference number	28435255
e-ISSN	11782013
DOI	10.2147/ijn.s131304
Language	English
Publisher	Dove Medical Press
Publisher Date	2017-04-04
Access Restriction	Open
Rights License	The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. © 2017 Thangavel et al. This work is published and licensed by Dove Medical Press Limited
Subject Keyword	metallodrugs nanotechnology cancer treatment cell apoptosis DNA damage toxicity
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Organic Chemistry Drug Discovery Medicine Biomaterials Biophysics Bioengineering Pharmaceutical Science