NDLI: Protective effect of <i>Crocus sativus</i> L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats.

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Protective effect of Crocus sativus L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats.

Content Provider	Europe PMC
Author	Farjah, Gholam Hossein Salehi, Shadi Ansari, Mohammad Hasan Pourheidar, Bagher
Copyright Year	2017
Abstract	Objective(s):Ischemia/reperfusion (I/R) injury of spinal cord is leading to the paraplegia observed. In this study, we investigated the protective effect of the saffron extract on spinal cord I/R injury.Materials and Methods:Thirty five male Sprague-Dawley rats were divided into 5 groups: intact, sham surgery, normal saline (NS), low dose saffron aqua extract, high dose saffron aqua extract.Results:The mean motor deficit index (MDI) scores were significantly lower in the saffron extract groups than in the NS group at 48 hr after spinal cord ischemia (P<0.001). Saffron extract groups significantly decreased plasma level of malondialdehyde than in the NS Group (P<0.05). The number of motor normal neurons was significantly greater in the high saffron extract group than in the NS and low saffron group (P<0.05).Conclusion:These data suggest that a saffron extract may protect spinal cord neurons from I/R injury.
ISSN	20083866
Journal	Iranian Journal of Basic Medical Sciences
Volume Number	20
PubMed Central reference number	PMC5378972
Issue Number	3
PubMed reference number	28392907
e-ISSN	20083874
DOI	10.22038/IJBMS.2017.8364
Language	English
Publisher	Mashhad University of Medical Sciences
Publisher Date	2017-03-01
Publisher Place	Iran
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright: © Iranian Journal of Basic Medical Sciences
Subject Keyword	Ischemia Reperfusion Spinal cord Saffron extract
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Drug Discovery Clinical Biochemistry Biochemistry Biophysics

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