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New approaches regarding the in vitro maturation of oocytes: manipulating cyclic nucleotides and their partners in crime.
| Content Provider | Europe PMC |
|---|---|
| Author | Botigelli, Ramon Cesar Razza, Eduardo Montanari Pioltine, Elisa Mariano Nogueira, Marcelo Fábio Gouveia |
| Abstract | Several discoveries have been described recently (5-10 years) about the biologyof ovarian follicles (oocyte, cumulus cells and granulosa cells), including newaspects of cellular communication, the control of oocyte maturation and theacquisition of oocyte competence for fertilization and further embryodevelopment. These advances are nourishing assisted reproduction techniques(ART) with new possibilities, in which novel culture systems are being developedand tested to improve embryo yield and quality. This mini-review aims todescribe how the recent knowledge on the physiological aspects of mammalianoocyte is reflecting as original or revisited approaches into the context ofembryo production. These new insights include recent findings on the mechanismsthat control oocyte maturation, especially modulating intraoocyte levels ofcyclic nucleotides during in vitro maturation using endogenousor exogenous agents. In this mini-review we also discuss the positive andnegative effects of these manipulations on the outcoming embryo |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5365199&blobtype=pdf |
| ISSN | 15175693 |
| Journal | JBRA Assisted Reproduction [JBRA Assist Reprod] |
| Volume Number | 21 |
| DOI | 10.5935/1518-0557.20170010 |
| PubMed Central reference number | PMC5365199 |
| Issue Number | 1 |
| PubMed reference number | 28333031 |
| e-ISSN | 15180557 |
| Language | English |
| Publisher | Brazilian Society of Assisted Reproduction |
| Publisher Date | 2017-02-01 |
| Access Restriction | Open |
| Rights License | This is an Open Access article distributed under the terms of theCreative Commons Attribution License, which permits unrestricted use,distribution, and reproduction in any medium, provided the original work isproperly cited. |
| Subject Keyword | Oocytes cumulus cells oocyte in vitro maturation cyclic nucleotides in vitro oocyte maturation techniques |
| Content Type | Text |
| Resource Type | Article |
| Subject | Obstetrics and Gynecology |
