A Clinical Trial of the Accuracy and Treatment Experience of the Flash Glucose Monitor FreeStyle Libre in Adults with Type 1 Diabetes.

Content Provider	Europe PMC
Author	Ólafsdóttir, Arndís F. Attvall, Stig Sandgren, Ulrika Dahlqvist, Sofia Pivodic, Aldina Skrtic, Stanko Theodorsson, Elvar Lind, Marcus
Copyright Year	2017
Abstract	AbstractBackground: In Sweden, FreeStyle Libre a flash glucose monitoring system came onto the market in 2014 as a complement to self-monitoring of blood glucose. The aim of this study was to evaluate the accuracy and treatment experience of the FreeStyle Libre system.Methods: Fifty-eight adults with type 1 diabetes used FreeStyle Libre for 10–14 days and measured capillary blood glucose levels with the HemoCue blood glucose measurement system at least six times a day simultaneously.Results: For the entire study period, the mean absolute relative difference (MARD) was 13.2% (95% confidence interval [CI] 12.0%–14.4%). MARD was 13.6% (95% CI 12.1%–15.4%) during week 1 and 12.7% (95% CI 11.5%–13.9%) during week 2. The mean absolute difference (MAD) for the whole study period was 19.8 mg/dL (1.1 mmol/L) (95% CI 17.8–21.8 mg/dL), including 20.5 mg/dL (1.14 mmol/L) during week 1 and 19.0 mg/dL (1.05 mmol/L) during week 2. The overall correlation coefficient was 0.96. For glucose values <72, 72–180, and >180 mg/dL (<4, 4–10, and >10 mmol/L), the MARD was 20.3% (95% CI 17.7%–23.1%), 14.7% (95% CI 13.4%–16%), and 9.6% (95% CI 8.5%–10.8%), respectively, and respective MAD values were 12.3, 17.8, and 23.6 mg/dL (0.69, 0.99, and 1.31 mmol/L). Using the 10-item visual analog scale, patients rated their experience with FreeStyle Libre as generally positive, with mean values ranging from 8.22 to 9.8.Conclusions: FreeStyle Libre had a similar overall MARD as continuous blood glucose monitoring systems in earlier studies when studied in similar at-home conditions. The overall patient satisfaction was high.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5359691&blobtype=pdf
Page Count	9
ISSN	15209156
Journal	Diabetes Technology & Therapeutics [Diabetes Technol Ther]
Volume Number	19
DOI	10.1089/dia.2016.0392
PubMed Central reference number	PMC5359691
Issue Number	3
PubMed reference number	28263665
e-ISSN	15578593
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2017-03-06
Publisher Place	140 Huguenot Street, 3rd FloorNew Rochelle, NY 10801USA
Access Restriction	Open
Rights License	This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. © Arndís F. Ólafsdóttir et al., 2017; Published by Mary Ann Liebert, Inc.
Subject Keyword	Diabetes mellitus Flash glucose monitor Accuracy
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Medical Laboratory Technology Endocrinology