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Are neurological complications of monoclonal gammopathy of undetermined significance underestimated?
| Content Provider | Europe PMC |
|---|---|
| Author | Steiner, Normann Schwärzler, Angelika Göbel, Georg Löscher, Wolfgang Wanschitz, Julia Gunsilius, Eberhard |
| Copyright Year | 2017 |
| Abstract | ObjectivesMonoclonal gammopathy of undetermined significance (MGUS) is a premalignancy preceding multiple myeloma (MM) or related disorders. Neurological symptoms caused by the monoclonal immunoglobulins or free light-chains are often associated with a high morbidity. We analyzed the prevalence of neuropathy, clinical features and the long-term outcome in 223 patients (pts.) with MGUS.Patients and MethodsBetween 1/2005 and 3/2015, 223 adult pts. with MGUS were identified in our database.ResultsIn36/223 pts. (16%) a neuropathy was diagnosed (MGUS associated neuropathy, MGUS-N). 20 pts. (55%) had a distal symmetric axonal neuropathy, 10 pts. (28%) had a chronic inflammatory demyelinating polyneuropathy and 6 pts (17%) a distal acquired demyelinating symmetric polyneuropathy. In MGUS-NN (without neuropathy) and in MGUS-N, progression to smoldering MM, MM or Waldenstrom's macroglobulinemia (WM) occurred in 17% of the pts. The Immunoglobulin subtype was predominantly IgG in MGUS-NN and IgM in MGUS-N and ≥5.5% plasma cells in the bone-marrow predicted progression to MM and AL-amyloidosis in MGUS-NN and to WM in MGUS-N (p<0.05).ConclusionDue to the substantial prevalence of neuropathies, MGUS pts. should be monitored carefully and referred to a specialized center if neurological symptoms occur. |
| Journal | Oncotarget |
| Volume Number | 8 |
| PubMed Central reference number | PMC5354894 |
| Issue Number | 3 |
| PubMed reference number | 27974705 |
| e-ISSN | 19492553 |
| DOI | 10.18632/oncotarget.13861 |
| Language | English |
| Publisher | Impact Journals LLC |
| Publisher Date | 2017-01-01 |
| Access Restriction | Open |
| Rights License | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright: © 2017 Steiner et al. |
| Subject Keyword | monoclonal gammopathy of undetermined significance MGUS MGUS associated neuropathy multiple myeloma |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oncology |
