NDLI: Dysbiosis of urinary microbiota is positively correlated with type 2 diabetes mellitus.

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Dysbiosis of urinary microbiota is positively correlated with type 2 diabetes mellitus.

Content Provider	Europe PMC
Author	Liu, Fengping Ling, Zongxin Xiao, Yonghong Lv, Longxian Yang, Qing Wang, Baohong Lu, Haifeng Zheng, Li Jiang, Ping Wang, Wei Li, Lanjuan
Copyright Year	2017
Abstract	Type 2 diabetes mellitus (T2DM) may be associated with altered urinary microbiota in female patients. We investigated alterations of urinary microbiota in Chinese female T2DM patients, and explored the associations between urinary microbiota and a patient’s fasting blood glucose (FBG), urine glucose (UGLU), age, menstrual status, and body mass index (BMI). Midstream urine was collected from 70 female T2DM patients and 70 healthy females. Microbial diversity and composition were analyzed using the Illumina MiSeq sequencing platform by targeting the hypervariable V3-V4 regions of the 16S rRNA gene. We found that bacterial diversity was decreased in T2DM patients. Increased Actinobacteria phylum was positively correlated with FBG, UGLU, and BMI; Lactobacillus abundance decreased with age and menopause; and increased Lactobacillus correlated positively with FBG and UGLU. Decreased Akkermansia muciniphila was associated with FBG and UGLU. Escherichia coli abundance did not differ between the two cohorts. Carbohydrate and amino acid metabolism was reduced in T2DM patients, which were associated with bacterial richness indices such as Chao1 and ACE. Detailed microbiota analysis of well-characterized T2DM patients and healthy controls indicate that Chinese T2DM female patients exhibit dysbiosis of urinary microbiota.
Journal	Oncotarget
Volume Number	8
PubMed Central reference number	PMC5354796
Issue Number	3
PubMed reference number	28008148
e-ISSN	19492553
DOI	10.18632/oncotarget.14028
Language	English
Publisher	Impact Journals LLC
Publisher Date	2017-01-01
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright: © 2017 Liu et al.
Subject Keyword	Akkermansia muciniphila Escherichia coli lactobacillus type 2 diabetes mellitus urinary microbiota Immunology and Microbiology Section Immune response Immunity
Content Type	Text
Resource Type	Article
Subject	Oncology

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