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Sudden infant death syndrome due to long QT syndrome: a brief review of the genetic substrate and prevalence.

Content Provider	Europe PMC
Author	Ioakeimidis, Nikolaos S. Papamitsou, Theodora Meditskou, Soultana Iakovidou-Kritsi, Zafiroula
Abstract	The pathophysiological mechanisms which lead to sudden infant death syndrome (SIDS) are not completely understood. Cardiac channelopathies are a well-established causative factor with long QT syndrome (LQTS) being the most frequent one, accounting for approximately 12% of SIDS cases. The genetic substrate of the above arrhythmogenic syndrome has been thoroughly described but only specific gene mutations or polymorphisms have been identified as SIDS causative. The review will focus on the prevalence of LQTS-induced SIDS or near-SIDS cases and the mutations held responsible. A literature search was performed in PubMed and Scopus electronic databases. Search terms used were: long QT syndrome, channelopathies, QT prolongation, cardiac ion channels. The above-mentioned search terms were always combined with the term: sudden infant death syndrome. Study types considered eligible were: case–control, family pedigree analysis, case reports. The prevalence of LQTS-induced SIDS according to six broad genetic studies ranges from 3.9 to 20.6%, with an average of 12%. Since LQTS can be effectively managed, LQTS-related SIDS cases could be prevented, provided that a screening method is efficient enough to detect all the affected infants.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5348737&blobtype=pdf
ISSN	1790045X
Volume Number	24
DOI	10.1186/s40709-017-0063-1
PubMed Central reference number	PMC5348737
PubMed reference number	28316956
Journal	Journal of Biological Research [J Biol Res (Thessalon)]
e-ISSN	22415793
Language	English
Publisher	BioMed Central
Publisher Date	2017-03-14
Publisher Place	London
Access Restriction	Open
Rights License	Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. © The Author(s) 2017
Subject Keyword	Sudden infant death Long QT syndrome Prevalence
Content Type	Text
Resource Type	Article
Subject	Biochemistry, Genetics and Molecular Biology Agricultural and Biological Sciences

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