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Factors associated with time to achieve an undetectable HIV RNA viral load after start of antiretroviral treatment in HIV-1-infected pregnant women.
| Content Provider | Europe PMC |
|---|---|
| Author | Snippenburg, W Nellen, FJB Smit, C Wensing, AMJ Godfried, MH Mudrikova, T |
| Abstract | AbstractObjectiveTo identify factors associated with the time to viral suppression in women starting antiretroviral treatment (ART) during pregnancy. Knowledge on duration of viral load (VL) decline could help deciding the timing of treatment initiation.MethodsHighly active antiretroviral treatment (HAART)-naive pregnant women over 18 years of age who started treatment during pregnancy were included. The time to viral suppression was calculated and compared between subgroups.ResultsA total of 227 pregnancies matched our inclusion criteria. In 84.6% of these an undetectable VL was reached at the time of delivery. The median time to undetectable VL after initiation of treatment was 60 days (12–168 days). Only baseline VL <10,000 copies/mL showed an independent association with time to viral suppression in multivariate Cox regression analysis, with a mean time to reach a VL <50 HIV-1 copies/mL of 49 days (95% CI 44–53). No difference in time to undetectable VL was found between protease inhibitor and non-nucleoside reverse transcriptase inhibitor-based regimens. Integrase inhibitors were not part of any treatment regimen.ConclusionOur results suggest that in patients with baseline HIV RNA <10,000 copies/mL ART initiation might be postponed up to the twentieth week of pregnancy, thus minimising the risk of possible drug-related teratogenicity and toxicity. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5337419&blobtype=pdf |
| ISSN | 20556640 |
| Journal | Journal of Virus Eradication [J Virus Erad] |
| Volume Number | 3 |
| PubMed Central reference number | PMC5337419 |
| Issue Number | 1 |
| PubMed reference number | 28275456 |
| e-ISSN | 20556659 |
| Language | English |
| Publisher | Mediscript Ltd |
| Publisher Date | 2017-01-01 |
| Access Restriction | Open |
| Rights License | This is an open access article published under the terms of a Creative Commons License. © 2017 The Authors. Journal of Virus Eradication published by Mediscript Ltd |
| Subject Keyword | pregnancy HIV suppression undetectable |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Virology Public Health, Environmental and Occupational Health Immunology Epidemiology |
