Antinociceptive effect of extracts of Marrubium astracanicum Jacq. aerial parts.

Content Provider	Europe PMC
Author	Kahkeshani, Niloofar Gharedaghi, Milad Hadjiakhoondi, Abbas Sharifzadeh, Mohammad Khanavi, Mahnaz
Abstract	Objective:The genus Marrubium is used for treatment of joint pain, gout, stomach-ache and colic in Iranian Traditional Medicine. Marrubium astracanicum Jacq. (M. astracanicum) is a native species in the flora of Iran. The aim of this study was to evaluate the antinociceptive properties of various extracts of aerial parts of M. astracanicum.Materials and Methods:Antinociceptive activities of total hydroalcoholic extract (THE) and its n-hexane (non-polar) and residual partition (polar) fractions were analyzed using formalin test in mice. Morphine (5 mg/kg) and normal saline were used as positive and negative controls, respectively.Results:Intraperitoneal administration of THE (50, 100 and 200 mg/kg), non-polar fraction (200 mg/kg) and polar fraction (100 and 200 mg/kg), 30 min before formalin injection, caused significant analgesic activity in acute phase (0-5 min after formalin injection) of formalin test (p<0.05 as compared to control and p>0.05 in comparison with morphine). In chronic phase (15–60 min after formalin injection), non-polar and polar fractions (50, 100 and 200 mg/kg) showed significant analgesic activity (p<0.001 as compared to control and p>0.05 in comparison with morphine).Conclusion:Different extracts of M. astracanicum demonstrated antinociceptive activity that support the traditional usage of Marrubium genus for the treatment of arthritis, gout and other inflammatory diseases.
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ISSN	22287930
Journal	Avicenna Journal of Phytomedicine [Avicenna J Phytomed]
Volume Number	7
PubMed Central reference number	PMC5329179
Issue Number	1
PubMed reference number	28265549
e-ISSN	22287949
Language	English
Publisher	Mashhad University of Medical Sciences
Publisher Date	2017-01-01
Publisher Place	Mashhad, Iran
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Subject Keyword	Marrubium astracanicum Pain measurement Analgesic
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Complementary and Alternative Medicine