Investigation of the Regulatory Effects of Saccharin on Cytochrome P450s in Male ICR Mice.

Content Provider	Europe PMC
Author	Jo, Jun Hyeon Kim, Sunjoo Jeon, Tae Won Jeong, Tae Cheon Lee, Sangkyu
Copyright Year	2017
Abstract	Saccharin, the first artificial sweetener, was discovered in 1879 that do not have any calories and is approximately 200~700 times sweeter than sugar. Saccharin was the most common domestically produced sweetener in Korea in 2010, and it has been used as an alternative to sugar in many products. The interaction between artificial sweeteners and drugs may affect the drug metabolism in patients with diabetes, cancer, and liver damage, this interaction has not been clarified thus far. Here, we examined the effects of the potential saccharin-drug interaction on the activities of 5 cytochrome P450 (CYPs) in male ICR mice; further, we examined the effects of saccharin (4,000 mg/kg) on the pharmacokinetics of bupropion after pretreatment of mice with saccharin for 7 days and after concomitant administration of bupropion and saccharin. Our results showed saccharin did not have a significant effect on the 5 CYPs in the S9 fractions obtained from the liver of mice. In addition, we observed no differences in the pharmacokinetic parameters of bupropion between the control group and the groups pretreated with saccharin and that receiving concomitant administration of saccharin. Thus, our results showed that saccharin is safe and the risk of saccharin-drug interaction is very low.
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ISSN	19768257
Journal	Toxicological Research [Toxicol Res]
Volume Number	33
PubMed Central reference number	PMC5266375
Issue Number	1
PubMed reference number	28133510
e-ISSN	22342753
DOI	10.5487/tr.2017.33.1.025
Language	English
Publisher	Korean Society of Toxicology
Publisher Date	2017-01-15
Access Restriction	Open
Rights License	This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2017 The Korean Society Of Toxicology
Subject Keyword	Artificial sweetener Saccharin Cytochrome P450 Pharmacokinetics Drug interaction
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology