NDLI: Dexmedetomidine alleviates cerebral ischemia-induced short-term memory impairment by inhibiting the expression of apoptosis-related molecules in the hippocampus of gerbils.

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Dexmedetomidine alleviates cerebral ischemia-induced short-term memory impairment by inhibiting the expression of apoptosis-related molecules in the hippocampus of gerbils.

Content Provider	Europe PMC
Author	Choi, In-Young Hwang, Lakkyong Jin, Jun-Jang Ko, Il-Gyu Kim, Sung-Eun Shin, Mal-Soon Shin, Key-Moon Kim, Chang-Ju Park, Sung-Wook Han, Jin-Hee Yi, Jae-Woo
Copyright Year	2016
Abstract	Cerebral ischemia results from cerebrovascular occlusion, which leads to neuronal cell death and eventually causes neurological impairments. Dexmedetomidine is a potent and highly selective α2-adrenoreceptor agonist with actions such as sedation, anxiolysis, analgesia and anesthetic-sparing effects. We investigated the effect of dexmedetomidine on apoptosis in the hippocampus after transient global ischemia in gerbils. Transient global ischemia was induced by ligation of both common carotid arteries. Dexmedetomidine was administrated intraperitoneally at three respective doses (0.1, 1 and 10 µg/kg) once per day for 14 consecutive days beginning a day after surgery. Short-term memory was assessed by use of a step-down avoidance task. Apoptosis was evaluated by terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling assay, immunohistochemistry for caspase-3, and western blot analysis of Bcl-2-associated X protein, B-cell lymphoma 2, Bid, cytochrome c, apoptotic protease activating factor-1 and caspase-9 in the hippocampus. Induction of global ischemia deteriorated short-term memory by enhancing the expression of apoptosis-related molecules in the hippocampus. Treatment with dexmedetomidine suppressed the expression of apoptosis-related molecules under ischemic conditions, resulting in short-term memory improvement. Under normal conditions, dexmedetomidine exerted no significant effect on apoptosis in the hippocampus. The present results suggest that the α2-adrenoceptor agonist dexmedetomidine may be a useful therapeutic agent for the treatment of ischemic brain diseases.
ISSN	17920981
Journal	Experimental and Therapeutic Medicine
Volume Number	13
PubMed Central reference number	PMC5244889
Issue Number	1
PubMed reference number	28123477
e-ISSN	17921015
DOI	10.3892/etm.2016.3956
Language	English
Publisher	D.A. Spandidos
Publisher Date	2016-12-05
Access Restriction	Open
Rights License	This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Copyright: © Choi et al.
Subject Keyword	transient global ischemia dexmedetomidine α2-adrenergic receptor apoptosis short-term memory gerbils
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Cancer Research

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