Effect of Refractive Correction Error on Retinal Nerve Fiber Layer Thickness: A Spectralis Optical Coherence Tomography Study.

Content Provider	Europe PMC
Author	Ma, Xiaoli Chen, Yutong Liu, Xianjie Ning, Hong
Copyright Year	2016
Abstract	BackgroundIdentifying and assessing retinal nerve fiber layer defects are important for diagnosing and managing glaucoma. We aimed to investigate the effect of refractive correction error on retinal nerve fiber layer (RNFL) thickness measured with Spectralis spectral-domain optical coherence tomography (SD-OCT).Material/MethodsWe included 68 participants: 32 healthy (normal) and 36 glaucoma patients. RNFL thickness was measured using Spectralis SD-OCT circular scan. Measurements were made with a refractive correction of the spherical equivalent (SE), the SE+2.00D and the SE–2.00D.ResultsAverage RNFL thickness was significantly higher in the normal group (105.88±10.47 μm) than in the glaucoma group (67.67±17.27 μm, P<0.001). In the normal group, +2.00D of refractive correction error significantly affected measurements of average (P<0.001) and inferior quadrant (P=0.037) RNFL thickness. In the glaucoma group, +2.00D of refractive correction error significantly increased average (P<0.001) and individual quadrant (superior: P=0.016; temporal: P=0.004; inferior: P=0.008; nasal: P=0.003) RNFL measurements compared with those made with the proper refractive correction. However, −2.00D of refractive correction error did not significantly affect RNFL thickness measurements in either group.ConclusionsPositive defocus error significantly affects RNFL thickness measurements made by the Spectralis SD-OCT. Negative defocus error did not affect RNFL measurement examined. Careful correction of refractive error is necessary to obtain accurate baseline and follow-up RNFL thickness measurements in healthy and glaucomatous eyes.
ISSN	12341010
Journal	Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Volume Number	22
PubMed Central reference number	PMC5215193
PubMed reference number	28030536
e-ISSN	16433750
DOI	10.12659/msm.898564
Language	English
Publisher	International Scientific Literature, Inc.
Publisher Date	2016-12-28
Access Restriction	Open
Rights License	This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) © Med Sci Monit, 2016
Subject Keyword	Glaucoma Refractive Errors Retina Tomography, Optical Coherence
Content Type	Text
Resource Type	Article
Subject	Medicine