Neutrophil Extravasation Cascade: What Can We Learn from Two-photon Intravital Imaging?

Content Provider	Europe PMC
Author	Park, Sang A Hyun, Young-Min
Copyright Year	2016
Abstract	Immune cells (leukocytes or white blood cells) move actively and sensitively based on body conditions. Despite their important role as protectors inside the body, it is difficult to directly observe the spatiotemporal momentum of leukocytes. With advances in imaging technology, the introduction of two-photon microscopy has enabled researchers to look deeper inside tissues in a three-dimensional manner. In observations of immune cell movement along the blood vessel, vascular permeability and innate immune cell movements remain unclear. Here, we describe the neutrophil extravasation cascade, which were observed using a two-photon intravital imaging technique. We also provide evidence for novel mechanisms such as neutrophil body extension and microparticle formation as well as their biological roles during migration.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5195840&blobtype=pdf
ISSN	15982629
Journal	Immune Network [Immune Netw]
Volume Number	16
DOI	10.4110/in.2016.16.6.317
PubMed Central reference number	PMC5195840
Issue Number	6
PubMed reference number	28035206
e-ISSN	20926685
Language	English
Publisher	The Korean Association of Immunologists
Publisher Date	2016-12-22
Access Restriction	Open
Rights License	This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2016 The Korean Association of Immunologists
Subject Keyword	Neutrophil extravasation Microparticle formation Two-photon microscopy Intravital imaging
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Immunology and Allergy Immunology