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Analysis of ROC: The value of HPV16 E6 protein in the diagnosis of early stage cervical carcinoma and precancerous lesions.
| Content Provider | Europe PMC |
|---|---|
| Author | Sun, Li Xu, Shubin Liang, Lei Zhao, Liang Zhang, Lei |
| Copyright Year | 2016 |
| Abstract | Cervical carcinoma is a multifactorial malignant tumor and diagnosis is therefore crucial. The aim of the present study was to examine the value of E6 oncoprotein, in human papillomavirus type 16 (HPV16), in the diagnosis of early stage cervical carcinoma and precancerous lesions. Receiver operating characteristic curve was used to analyze accuracy of diagnosis. A total of 124 patients infected with HPV16 were included in the study. The patients had an average age of 46.7±6.9 years and duration of disease of 10.5±3.4 months. To determine the expression level of HPV16 E6 the immunohistochemical Elivision method was performed. Proportion/horizon positive cells were used to count the cells, and pathologic diagnosis was employed for analysis of the results. The average follow-up time was 2.6±0.7 years. Sensitivity and specificity of diagnosing HPV16 E16 at 1 and 2 years, respectively, were calculated. The diagnostic rate of cervical carcinoma increased with time, and the positive expression of HPV16 E6 was also increased with the development of the disease. Differences among groups were statistically significant (P<0.05). Sensitivity, specificity and accuracy (AUC) of HPV16 E6 diagnosis improved with time, and the differences were statistically significant (P<0.05). Thus, HPV16 E6 oncoprotein can be used as an indicator with good sensitivity and specificity to diagnose early cervical carcinoma and precancerous lesions. The results therefore showed that accuracy increased with the development of the disease. |
| ISSN | 17921074 |
| Journal | Oncology Letters |
| Volume Number | 12 |
| PubMed Central reference number | PMC4997991 |
| Issue Number | 3 |
| PubMed reference number | 27588123 |
| e-ISSN | 17921082 |
| DOI | 10.3892/ol.2016.4844 |
| Language | English |
| Publisher | D.A. Spandidos |
| Publisher Date | 2016-07-11 |
| Access Restriction | Open |
| Rights License | This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Copyright: © Sun et al. |
| Subject Keyword | human papillomavirus type 16 E6 protein cervical carcinoma precancerous lesions receiver operating characteristic |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
