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Synthesis, Biological Evaluation and Docking Analysis of Some Novel Quinazolin Derivatives as Antitumor Agents.

Content Provider	Europe PMC
Author	El-serwy, Walaa S. A. Mohamed, Neama M. M. Kassem, Emad Mahmoud, Khaled Mounier, M. M
Abstract	Different acid chlorides (2a-d) reacted with anthranilic acid to produce 2-substituted-3, 1-benzoxazin-4-one (3a-d) which was used as starting material to synthesize some condensed and non-condensed heterocyclic compounds by reaction with nitrogen nucleophiles e.g., hydrazine hydrate, and formamide. Some of the newly synthesized analogues were chosen to evaluate their cytotoxic activity against human carcinoma cell lines (HePG2– MCF7– A549). The docking and the cytotoxic activity results revealed that nearly all of the compounds containing N-phenyl aniline showed signiﬁcant inhibition for the three cell lines.
ISSN	17350328
Journal	Iranian Journal of Pharmaceutical Research : IJPR
Volume Number	15
PubMed Central reference number	PMC4986116
Issue Number	1
PubMed reference number	27610158
e-ISSN	17266890
Language	English
Publisher	Shaheed Beheshti University of Medical Sciences
Publisher Date	2016-01-01
Publisher Place	Tehran, Iran
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. © 2016 by School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services
Subject Keyword	Cytotoxic activity Benzoxazin Quinazolin Antitumor Docking analysis
Content Type	Text
Resource Type	Article
Subject	Pharmacology, Toxicology and Pharmaceutics Pharmacology (medical)

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