NDLI: Will targeting PI3K/Akt/mTOR signaling work in hematopoietic malignancies?

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Will targeting PI3K/Akt/mTOR signaling work in hematopoietic malignancies?

Content Provider	Europe PMC
Author	Gao, Yanan Yuan, Chase Y. Yuan, Weiping
Copyright Year	2016
Abstract	The constitutive activation of phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway has been demonstrated to be critical in clinical cancer patients as well as in laboratory cancer models including hematological malignancies. Great efforts have been made to develop inhibitors targeting this pathway in hematological malignancies but so far the efficacies of these inhibitors were not as good as expected. By analyzing existing literatures and datasets available, we found that mutations of genes in the pathway only constitute a very small subset of hematological malignancies. Deep understanding of the function of gene, the pathway and/or its regulators, and the cellular response to inhibitors, may help us design better drugs targeting the hematological malignancies.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4981705&blobtype=pdf
ISSN	23069759
Volume Number	3
DOI	10.21037/sci.2016.07.02
PubMed Central reference number	PMC4981705
PubMed reference number	27583254
Journal	Stem Cell Investigation [Stem Cell Investig]
e-ISSN	23130792
Language	English
Publisher	AME Publishing Company
Publisher Date	2016-07-22
Access Restriction	Open
Rights License	2016 Stem Cell Investigation. All rights reserved.
Subject Keyword	Phosphatidylinositol 3-kinase (PI3K) protein kinase B (Akt) mammalian target of rapamycin (mTOR) hematological malignancies genetic analysis
Content Type	Text
Resource Type	Article
Subject	Cell Biology Genetics Developmental Biology Molecular Biology

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