NDLI: Effect of Topical Platelet-Rich Plasma on Burn Healing After Partial-Thickness Burn Injury.

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Effect of Topical Platelet-Rich Plasma on Burn Healing After Partial-Thickness Burn Injury.

Content Provider	Europe PMC
Author	Ozcelik, Umit Ekici, Yahya Bircan, Huseyin Yuce Aydogan, Cem Turkoglu, Suna Ozen, Ozlem Moray, Gokhan Haberal, Mehmet
Copyright Year	2016
Abstract	BackgroundTo investigate the effects of platelet-rich plasma on tissue maturation and burn healing in an experimental partial-thickness burn injury model.Material/MethodsThirty Wistar albino rats were divided into 3 groups of 10 rats each. Group 1 (platelet-rich plasma group) was exposed to burn injury and topical platelet-rich plasma was applied. Group 2 (control group) was exposed to burn injury only. Group 3 (blood donor group) was used as blood donors for platelet-rich plasma. The rats were killed on the seventh day after burn injury. Tissue hydroxyproline levels were measured and histopathologic changes were examined.ResultsHydroxyproline levels were significantly higher in the platelet-rich plasma group than in the control group (P=.03). Histopathologically, there was significantly less inflammatory cell infiltration (P=.005) and there were no statistically significant differences between groups in fibroblast development, collagen production, vessel proliferations, or epithelization.ConclusionsPlatelet-rich plasma seems to partially improve burn healing in this experimental burn injury model. As an initial conclusion, it appears that platelet-rich plasma can be used in humans, although further studies should be performed with this type of treatment.
ISSN	12341010
Journal	Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Volume Number	22
PubMed Central reference number	PMC4913826
PubMed reference number	27262706
e-ISSN	16433750
DOI	10.12659/msm.895395
Language	English
Publisher	International Scientific Literature, Inc.
Publisher Date	2016-06-05
Access Restriction	Open
Rights License	This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) © Med Sci Monit, 2016
Subject Keyword	Burns Models, Animal Platelet-Rich Plasma Wound Healing
Content Type	Text
Resource Type	Article
Subject	Medicine

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