NDLI: Molecularly imprinted polymers as the extracted sorbents of clenbuterol ahead of liquid chromatographic determination.

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Molecularly imprinted polymers as the extracted sorbents of clenbuterol ahead of liquid chromatographic determination.

Content Provider	Europe PMC
Author	Lay, Sovichea Yu, Hai-ning Hu, Bao-xiang Shen, Sheng-rong
Copyright Year	2016
Abstract	A pre-treatment methodology for clenbuterol hydrochloride (CLEN) isolation and enrichment in a complex matrix environment was developed through exploiting molecularly imprinted polymers (MIPs). CLEN-imprinted polymers were synthesized by the combined use of ally-β-cyclodextrin (ally-β-CD) and methacrylic acid (MAA), allyl-β-CD and acrylonitrile (AN), and allyl-β-CD and methyl methacrylate (MMA) as the binary functional monomers. MAA-linked allyl-β-CD MIPs (M-MAA) were characterized by Fourier transform-infrared (FT-IR) spectroscopy and a scanning electron microscope (SEM). Based upon the results, M-MAA polymers generally proved to be an excellent selective extraction compared to its references: AN-linked allyl-β-CD MIPs (M-AN) and MMA-linked allyl-β-CD MIPs (M-MMA). M-MAA polymers were eventually chosen to run through a molecularly imprinted solid-phase extraction (MISPE) micro-column to enrich CLEN residues spiked in pig livers. A high recovery was achieved, ranging from 91.03% to 96.76% with relative standard deviation (RSD) ≤4.45%.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4913795&blobtype=pdf
ISSN	16731581
Volume Number	17
PubMed Central reference number	PMC4913795
Issue Number	6
PubMed reference number	27256680
Journal	Journal of Zhejiang University. Science. B [J Zhejiang Univ Sci B]
e-ISSN	18621783
DOI	10.1631/jzus.b1500225
Language	English
Publisher	Zhejiang University Press
Publisher Date	2016-06-01
Publisher Place	Hangzhou
Access Restriction	Open
Rights License	Copyright © Zhejiang University and Springer-Verlag Berlin Heidelberg 2016
Subject Keyword	Molecularly imprinted polymer (MIP) Molecularly imprinted solid-phase extraction (MISPE) Clenbuterol Cyclodextrin
Content Type	Text
Resource Type	Article
Subject	Veterinary Medicine Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics

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