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Immune checkpoint blockade therapy for bladder cancer treatment.
| Content Provider | Europe PMC |
|---|---|
| Author | Kim, Jayoung |
| Copyright Year | 2016 |
| Abstract | Bladder cancer remains the most immunogenic and expensive malignant tumor in the United States today. As the 4th leading cause of death from cancer in United States, Immunotherapy blocking immune checkpoints have been recently been applied to many aggressive cancers and changed interventions of urological cancers including advanced bladder cancer. The applied inhibition of PD-1–PD-L1 interactions can restore antitumor T-cell activity and enhance the cellular immune attack on antigens. The overall goals of this short review article are to introduce current cancer immunotherapy and immune checkpoint inhibitors, and to provide new insight into the underlying mechanisms that block immune checkpoints in tumor microenvironment. Furthermore, this review will address the preclinical and clinical trials to determine whether bladder cancer patients could benefit from this new cancer therapy in near future. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4910761&blobtype=pdf |
| ISSN | 24660493 |
| Journal | Investigative and Clinical Urology [Investig Clin Urol] |
| Volume Number | 57 Suppl 1 |
| PubMed Central reference number | PMC4910761 |
| Issue Number | Suppl 1 |
| PubMed reference number | 27326412 |
| e-ISSN | 2466054X |
| DOI | 10.4111/icu.2016.57.s1.s98 |
| Language | English |
| Publisher | The Korean Urological Association |
| Publisher Date | 2016-05-26 |
| Access Restriction | Open |
| Rights License | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. © The Korean Urological Association, 2016 |
| Subject Keyword | Immune checkpoint PD-1 PD-L1 Bladder cancer Immune therapy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Urology |
