Peptide-coated gold nanoparticles for modulation of angiogenesis in vivo.

Content Provider	Europe PMC
Author	Roma-Rodrigues, Catarina Heuer-Jungemann, Amelie Fernandes, Alexandra R Kanaras, Antonios G Baptista, Pedro V
Copyright Year	2016
Abstract	In this work, peptides designed to selectively interact with cellular receptors involved in the regulation of angiogenesis were anchored to oligo-ethylene glycol-capped gold nanoparticles (AuNPs) and used to evaluate the modulation of vascular development using an ex ovo chick chorioallantoic membrane assay. These nanoparticles alter the balance between naturally secreted pro- and antiangiogenic factors, under various biological conditions, without causing toxicity. Exposure of chorioallantoic membranes to AuNP–peptide activators of angiogenesis accelerated the formation of new arterioles when compared to scrambled peptide-coated nanoparticles. On the other hand, antiangiogenic AuNP–peptide conjugates were able to selectively inhibit angiogenesis in vivo. We demonstrated that AuNP vectorization is crucial for enhancing the effect of active peptides. Our data showed for the first time the effective control of activation or inhibition of blood vessel formation in chick embryo via AuNP-based formulations suitable for the selective modulation of angiogenesis, which is of paramount importance in applications where promotion of vascular growth is desirable (eg, wound healing) or ought to be contravened, as in cancer development.
ISSN	11769114
Journal	International Journal of Nanomedicine
Volume Number	11
PubMed Central reference number	PMC4907718
PubMed reference number	27354794
e-ISSN	11782013
DOI	10.2147/ijn.s108661
Language	English
Publisher	Dove Medical Press
Publisher Date	2016-06-07
Access Restriction	Open
Rights License	The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. © 2016 Roma-Rodrigues et al. This work is published and licensed by Dove Medical Press Limited
Subject Keyword	angiogenesis activators antiangiogenic CAM assay gold nanoparticles peptide-coated gold nanoparticles vascular development
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Organic Chemistry Drug Discovery Medicine Biomaterials Biophysics Bioengineering Pharmaceutical Science