Selenoprotein M is expressed during bone development.

Content Provider	Europe PMC
Author	Grosch, Melanie Fuchs, Jennifer Bösl, Michael Winterpacht, Andreas Tagariello, Andreas
Copyright Year	2013
Abstract	25 selenoproteins that contain selenium, incorporated as selenocysteine (Sec), have been identified to date. Selenoprotein M (SELM) is one of seven endoplasmic reticulum (ER)-resident, Sec-containing proteins that may be involved in posttranslational processing of proteins and maintenance of ER function. Since SELM was overrepresented in a cartilage- and bone-specific expressed sequence tag (EST) library, we further investigated the expression pattern of Selm and its possible biological function in the skeleton. RNA in situ hybridization of Selm in chicken and mice of different developmental stages revealed prominent expression in bones, specifically in osteoblast, and in tendons. This result suggests that SELM functions during bone development, where it is possibly involved in the processing of secreted proteins.
Journal	EXCLI Journal
Volume Number	12
PubMed Central reference number	PMC4904744
PubMed reference number	27298612
e-ISSN	16112156
Language	English
Publisher	Leibniz Research Centre for Working Environment and Human Factors
Publisher Date	2013-11-20
Access Restriction	Open
Rights License	This is an Open Access article distributed under the following Assignment of Rights http://www.excli.de/documents/assignment_of_rights.pdf. You are free to copy, distribute and transmit the work, provided the original author and source are credited. Copyright © 2013 Grosch et al.
Subject Keyword	selenium selenoproteins Kashin-Beck osteoarthropathy bone development thiol-disulfide oxidoreductase unfolded protein response
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmacology Animal Science and Zoology Molecular Medicine