Lack of Association between Pre-Operative Insulin-Like Growth Factor-1 and the Risk of Post-Operative Delirium in Elderly Chinese Patients.

Content Provider	Europe PMC
Author	Chu, Che-Sheng Liang, Chih-Kuang Chou, Ming-Yueh Lin, Yu-Te Hsu, Chien-Jen Chu, Chin-Liang Chou, Po-Han
Copyright Year	2016
Abstract	ObjectivePostoperative delirium (POD) is a highly prevalent complex neuropsychiatric syndrome in elderly patients. However, its pathophysiology is currently unknown. Early detection and prevention of POD is important; therefore, the aim of this study was to investigate the link between preoperative insulin growth factor 1 (IGF-1) levels in the serum and POD in the Chinese elderly patients.MethodsOne hundred and three patients who were undergoing an orthopedic operation took part in the study. Preoperative serum IGF-1 levels were measured. POD was determined daily using the Confusion Assessment Method (CAM) and DSM-IV TR. Baseline serum IGF-1 levels were compared between patients who did and did not develop POD. Correlation coefficients were calculated to evaluate relationship between baseline characteristics and serum IGF-1 levels. The relationship between baseline biomarkers and delirium status was investigated using logistic regression analysis, adjusting for potential confounding variables.ResultsTwenty-three patients developed POD. The POD group had lower MMSE scores and higher CCI scores and proportions of acute admission. Preoperative serum IGF-1 levels were correlated with MMSE scores and age (MMSE: r=0.230, p<0.05; age: r=-0.419, p<0.001). Baseline serum IGF-1 levels did not differ between patients who did and did not develop POD, even after adjusting for potential confounding factors, MMSE score, and age.ConclusionNo association was found between preoperative IGF-1 levels and POD, suggesting that they are not direct biomarkers of the incidence of POD among the Chinese elderly population. Further research with larger sample sizes is warranted to clarify the relationship.
ISSN	17383684
Journal	Psychiatry Investigation
Volume Number	13
PubMed Central reference number	PMC4878968
Issue Number	3
PubMed reference number	27247600
e-ISSN	19763026
DOI	10.4306/pi.2016.13.3.327
Language	English
Publisher	Korean Neuropsychiatric Association
Publisher Date	2016-05-18
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2016 Korean Neuropsychiatric Association
Subject Keyword	IGF-1 Postoperative delirium Elderly
Content Type	Text
Resource Type	Article
Subject	Biological Psychiatry Psychiatry and Mental Health