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Optically monitored drug delivery patch based on porous silicon and polymer microneedles.
| Content Provider | Europe PMC |
|---|---|
| Author | Dardano, Principia Caliò, Alessandro Politi, Jane Rea, Ilaria Rendina, Ivo De Stefano, Luca |
| Copyright Year | 2016 |
| Abstract | Fabrication and characterization of an optically monitored hybrid patch for local administration of drugs, based on polymeric micro-needles and a porous silicon free-standing membrane, are reported. The micro-needles are realized by an innovative photolithographic approach that allows fine tuning of geometrical parameters, using polyethylene glycol and a commercial photo-catalyzer. The porous silicon multilayer not only increases the storage of a relevant amount of the drug, but also offers a continuous, naked-eye monitoring of the drug delivery process. As a proof-of-concept experiment, we report our results on the release of a dye molecule (fluorescein, 332 Da) in a phosphate saline buffer. |
| Journal | Biomedical Optics Express |
| Volume Number | 7 |
| PubMed Central reference number | PMC4871071 |
| Issue Number | 5 |
| PubMed reference number | 27231611 |
| e-ISSN | 21567085 |
| DOI | 10.1364/BOE.7.001645 |
| Language | English |
| Publisher | Optical Society of America |
| Publisher Date | 2016-04-04 |
| Access Restriction | Open |
| Rights License | © 2016 Optical Society of America |
| Subject Keyword | (170.0170) Medical optics and biotechnology (310.6845) Thin film devices and applications (160.5470) Polymers |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biotechnology Atomic and Molecular Physics, and Optics |
