NDLI: Manganese dioxide nanosheets-based redox/pH-responsive drug delivery system for cancer theranostic application.

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Manganese dioxide nanosheets-based redox/pH-responsive drug delivery system for cancer theranostic application.

Content Provider	Europe PMC
Author	Hao, Yongwei Wang, Lei Zhang, Bingxiang Li, Dong Meng, Dehui Shi, Jinjin Zhang, Hongling Zhang, Zhenzhong Zhang, Yun
Copyright Year	2016
Abstract	The aim of this study was to construct redox- and pH-responsive degradable manganese dioxide (MnO2) nanosheets for cancer theranostic application. The small MnO2 nanosheets were synthesized, and then functionalized by hyaluronic acid (HA), demonstrating excellent stability and tumor-targeting ability. Cisplatin (cis-diamminedichloroplatinum [CDDP]) was absorbed by the nanosheets through a physical action, which was designed as MnO2/HA/CDDP. The prepared MnO2/HA/CDDP formulation was able to efficiently deliver CDDP to tumor cells in vitro and in vivo, resulting in improved therapeutic efficiency. Subsequently, they were triggered by lower pH and higher level of reduced glutathione to generate Mn2+, enabling magnetic resonance imaging. The smart multifunctional system combining efficient magnetic resonance imaging and chemotherapy has the potential to be used as a tumor-targeting theranostic nanomedicine.
ISSN	11769114
Journal	International Journal of Nanomedicine
Volume Number	11
PubMed Central reference number	PMC4857809
PubMed reference number	27199556
e-ISSN	11782013
DOI	10.2147/ijn.s98832
Language	English
Publisher	Dove Medical Press
Publisher Date	2016-04-29
Access Restriction	Open
Rights License	The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. © 2016 Hao et al. This work is published and licensed by Dove Medical Press Limited
Subject Keyword	manganese dioxide nanosheets hyaluronic acid magnetic resonance imaging theranostic application
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Organic Chemistry Drug Discovery Medicine Biomaterials Biophysics Bioengineering Pharmaceutical Science

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