Prognostic and Clinicopathological Significance of Transducer-Like Enhancer of Split 1 Expression in Gastric Cancer.

Content Provider	Europe PMC
Author	Lee, Ji-Hye Son, Myoung-Won Kim, Kyung-Ju Oh, Mee-Hye Cho, Hyundeuk Lee, Hyun Ju Jang, Si-Hyong Lee, Moon Soo
Copyright Year	2016
Abstract	PurposeTransducer-like enhancer of split 1 (TLE1) is a member of the Groucho/TLE family of transcriptional co-repressors that regulate the transcriptional activity of numerous genes. TLE1 is involved in the tumorigenesis of various tumors. We investigated the prognostic significance of TLE1 expression and its association with clinicopathological parameters in gastric cancer (GC) patients.Materials and MethodsImmunohistochemical analysis of six tissue microarrays was performed to examine TLE1 expression using 291 surgically resected GC specimens from the Soonchunhyang University Cheonan Hospital between July 2006 and December 2009.ResultsIn the non-neoplastic gastric mucosa, TLE1 expression was negative. In GC, 121 patients (41.6%) were positive for TLE1. The expression of TLE1 was significantly associated with male gender (P=0.021), less frequent lymphatic (P=0.017) or perineural invasion (P=0.029), intestinal type according to the Lauren classification (P=0.024), good histologic grade (P<0.001), early pathologic T-stage (P=0.012), and early American Joint Committee on Cancer stage (P=0.022). In the Kaplan-Meier analysis, the TLE1 expression was significantly associated with longer disease-free (P=0.022) and overall (P=0.001) survival rates.ConclusionsWe suggested that TLE1 expression is a good prognostic indicator in GCs.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4834617&blobtype=pdf
ISSN	2093582X
Journal	Journal of Gastric Cancer [J Gastric Cancer]
Volume Number	16
DOI	10.5230/jgc.2016.16.1.21
PubMed Central reference number	PMC4834617
Issue Number	1
PubMed reference number	27104023
e-ISSN	20935641
Language	English
Publisher	The Korean Gastric Cancer Association
Publisher Date	2016-03-31
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2016 by The Korean Gastric Cancer Association
Subject Keyword	TLE1 Stomach neoplasms Survival Tissue array analysis
Content Type	Text
Resource Type	Article
Subject	Cancer Research Gastroenterology Oncology