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Poor Prognostic Factors in Patients with Parenteral Nutrition-Dependent Pediatric Intestinal Failure.
| Content Provider | Europe PMC |
|---|---|
| Author | Choi, Shin Jie Lee, Kyung Jae Choi, Jong Sub Yang, Hye Ran Moon, Jin Soo Chang, Ju Young Ko, Jae Sung |
| Copyright Year | 2016 |
| Abstract | PurposeParenteral nutrition (PN) not only provides nutritional support but also plays a crucial role in the treatment of children with intestinal failure. The aim of this study was to evaluate the clinical significance and clinical outcomes of long-term PN.MethodsRetrospective cohort study was conducted using the medical records of patients treated at Seoul National University Children's Hospital. This study included 19 patients who received PN for over six months. Most patients received home PN.ResultsThe indications for PN included short bowel syndrome, chronic intestinal pseudo-obstruction, and intractable diarrhea of infancy. The median age of PN initiation was 1.3 years, and the median treatment duration was 2.9 years. Two patients were weaned from PN; 14 continued to receive PN with enteral feedings; and 3 patients died. The overall survival rates at 2 and 5 years were 93.3% and 84.0%, respectively. The incidence of catheter-related bloodstream infections was 2.7/1,000 catheter-days and was associated with younger age at PN initiation and lower initial height Z-score. Six patients developed catheter-related central vein thrombosis, with an incidence of 0.25/1,000 catheter-days. Eleven patients experienced PN-associated liver disease (PNALD), and one patient underwent multi-visceral transplant. The patients with PNALD exhibited lower final heights and body weight Z-scores. All patients experienced micronutrient deficiencies transiently while receiving PN.ConclusionPN is an important and safe treatment for pediatric intestinal failure. PNALD was linked to final anthropometric poor outcomes. Micronutrient deficiencies were common. Anthropometric measurements and micronutrient levels must be monitored for successful PN completion. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4821982&blobtype=pdf |
| ISSN | 22348646 |
| Journal | Pediatric Gastroenterology, Hepatology & Nutrition [Pediatr Gastroenterol Hepatol Nutr] |
| Volume Number | 19 |
| DOI | 10.5223/pghn.2016.19.1.44 |
| PubMed Central reference number | PMC4821982 |
| Issue Number | 1 |
| PubMed reference number | 27066448 |
| e-ISSN | 22348840 |
| Language | English |
| Publisher | The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition |
| Publisher Date | 2016-03-22 |
| Access Restriction | Open |
| Rights License | This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2016 by The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition |
| Subject Keyword | Parenteral nutrition Catheter related infections Cholestasis Micronutrients |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hepatology Gastroenterology Pediatrics, Perinatology and Child Health |
