NDLI: PHARMACOLOGIC TREATMENT OF HYPERALGESIA EXPERIMENTALLY INDUCED BY NUCLEUS PULPOSUS.

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PHARMACOLOGIC TREATMENT OF HYPERALGESIA EXPERIMENTALLY INDUCED BY NUCLEUS PULPOSUS.

Content Provider	Europe PMC
Author	de Souza Grava, André Luiz Ferrari, Luiz Fernando Parada, Carlos Amílcar Defino, Helton Luiz Aparecido
Copyright Year	2010
Abstract	Objective: To evaluate the effect of anti-inflammatory drugs (dexamethasone, indomethacin, atenolol and indomethacin plus atenolol) and analgesic drugs (morphine) on hyperalgesia experimentally induced by the nucleus pulposus (NP) in contact with the L5 dorsal root ganglion (DRG). Methods: Thirty male Wistar rats of weights ranging from 220 to 250 g were used in the study. Hyperalgesia was induced by means of a fragment of NP removed from the sacrococcygeal region that was placed in contact with the L5 dorsal root ganglion. The 30 animals were divided into experimental groups according to the drug used. The drugs were administered for two weeks after the surgical procedure to induce hyperalgesia. Mechanical and thermal hyperalgesia was evaluated using the paw pressure test, von Frey electronic test and Hargreaves test, over a seven-week period. Results: The greatest reduction of hyperalgesia was observed in the group of animals treated with morphine, followed by dexamethasone, indomethacin and atenolol. Reductions in hyperalgesia were observed after drug administration ceased, except for the group of animals treated with morphine, in which there was an increase in hyperalgesia after discontinuation of the treatment. Conclusion: Hyperalgesia induced by NP contact with the DRG can be reduced through administration of anti-inflammatory and analgesic drugs, but a greater reduction was observed with the administration of dexamethasone.
Journal	Revista Brasileira de Ortopedia
Volume Number	45
PubMed Central reference number	PMC4799208
Issue Number	6
PubMed reference number	27026966
e-ISSN	22554971
DOI	10.1016/S2255-4971(15)30305-0
Language	English
Publisher	Elsevier
Publisher Date	2010-11-01
Access Restriction	Open
Rights License	This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). © 2010 Sociedade Brasileira de Ortopedia e Traumatologia
Subject Keyword	Spine Intervertebral Disc Low Back Pain Hyperalgesia Intervertebral Disc Displacement Wistar Rats
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine

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