Usefulness of Transcranial Magnetic Stimulation to Assess Motor Function in Patients With Parkinsonism.

Content Provider	Europe PMC
Author	Park, Jaechan Chang, Won Hyuk Cho, Jin Whan Youn, Jinyoung Kim, Yun Kwan Kim, Sun Woong Kim, Yun-Hee
Copyright Year	2016
Abstract	ObjectiveTo investigate the clinical significance of upper and lower extremity transcranial magnetic stimulation (TMS)-induced motor evoked potentials (MEPs) in patients with parkinsonism.MethodsTwenty patients (14 men, 6 women; mean age 70.5±9.1 years) suffering from parkinsonism were included in this study. All participants underwent single-pulse TMS session to assess the corticospinal excitability of the upper and lower extremity motor cortex. The resting motor threshold (RMT) was defined as the lowest stimulus intensity able to evoke MEPs of an at least 50 µV peak-to-peak amplitude in 5 of 10 consecutive trials. Five sweeps of MEPs at 120% of the RMT were performed, and the mean amplitude and latency of the MEPs were calculated. Patients were also assessed using the Unified Parkinson's Disease Rating Scale part III (UPDRS-III) and the 5-meter Timed Up and Go (5m-TUG) test.ResultsThere was a significant positive correlation between the RMTs of MEPs in the upper and lower extremities (r=0.612, p=0.004) and between the amplitude of MEPs in the upper and lower extremities (r=0.579, p=0.007). The RMT of upper extremity MEPs showed a significant negative relationship with the UPDRS-III score (r=–0.516, p=0.020). In addition, RMTs of lower extremity MEPs exhibited a negative relationship with the UPDRS-III score, but the association was not statistically significant (r=–406, p=0.075).ConclusionThese results indicated that the RMT of MEPs reflect the severity of motor dysfunction in patients with parkinsonism. MEP is a potential quantitative, electrodiagnostic method to assess motor function in patients with parkinsonism.
ISSN	22340645
Journal	Annals of Rehabilitation Medicine
Volume Number	40
PubMed Central reference number	PMC4775762
Issue Number	1
PubMed reference number	26949673
e-ISSN	22340653
DOI	10.5535/arm.2016.40.1.81
Language	English
Publisher	Korean Academy of Rehabilitation Medicine
Publisher Date	2016-02-26
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2016 by Korean Academy of Rehabilitation Medicine
Subject Keyword	Transcranial magnetic stimulation Motor evoked potentials Parkinsonian disorders Motor disorders
Content Type	Text
Resource Type	Article
Subject	Rehabilitation