Placental Transfer of Perfluoroalkyl Substances and Associations with Thyroid Hormones: Beijing Prenatal Exposure Study.

Content Provider	Europe PMC
Author	Yang, Lin Li, Jingguang Lai, Jianqiang Luan, Hemi Cai, Zongwei Wang, Yibaina Zhao, Yunfeng Wu, Yongning
Copyright Year	2016
Abstract	Perfluoroalkyl substances (PFASs) have been detected in wildlife and human samples worldwide. Toxicology research showed that PFASs could interfere with thyroid hormone homeostasis. In this study, eight PFASs, fifteen PFAS precursors and five thyroid hormones were analyzed in 157 paired maternal and cord serum samples collected in Beijing around delivery. Seven PFASs and two precursors were detected in both maternal and cord sera with significant maternal-fetal correlations (r = 0.336 to 0.806, all P < 0.001). The median ratios of major PFASs concentrations in fetal versus maternal serum were from 0.25:1 (perfluorodecanoic acid, PFDA) to 0.65:1 (perfluorooctanoic acid, PFOA). Spearman partial correlation test showed that maternal thyroid stimulating hormone (TSH) was negatively correlated with most maternal PFASs (r = -0.261 to -0.170, all P < 0.05). Maternal triiodothyronin (T3) and free T3 (FT3) showed negative correlations with most fetal PFASs (r = -0.229 to -0.165 for T3; r = -0.293 to -0.169 for FT3, all P < 0.05). Our results suggest prenatal exposure of fetus to PFASs and potential associations between PFASs and thyroid hormone homeostasis in humans.
Journal	Scientific Reports [Sci Rep]
Volume Number	6
DOI	10.1038/srep21699
PubMed Central reference number	PMC4762009
PubMed reference number	26898235
e-ISSN	20452322
Language	English
Publisher	Nature Publishing Group
Publisher Date	2016-02-22
Access Restriction	Open
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary