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Identification of CYP2C9 and VKORC1 polymorphisms in Iranian patients who are under warfarin therapy.
| Content Provider | Europe PMC |
|---|---|
| Author | Poopak, Behzad Rabieipoor, Saghar Safari, Nazila Naraghi, Emadedin Sheikhsofla, Fatemeh Khosravipoor, Gelareh |
| Abstract | Background: Although catalytic properties of different genetic polymorphisms of VKORC1 and CYP2C9 products have been identified, there is limited study available regarding warfarin dose requirement in Iranian patient population. This study investigates the impact of these polymorphisms on 115 patients, referred to Payvand Clinical and Specialty Laboratory for determining the appropriate dose of warfarin. Results of the study may be applicable to individuals who are under warfarin therapy to avoid warfarin resistance or intolerance.Subjects and Methods: PT-INR test was utilized as a screening method. Genotyping were performed for VKORC1 and CYP2C9 using PCR method. Statistical analyses including unpaired t-test or ANOVA and regression were done using SPSS.Results: VKORC1 GA was the most common genotype of VKORC1 allele among the study samples, with a rate of 57.4%. In CYP2C9 variant, 20% and 14.8% of subjects carried CYP2C9*1/*2 and CYP2C9*1/*3 genotyping, respectively. By contrast, the WT *1/*1 genotype was more abundant and dominant. The high frequency of VKORC1 (_1639) GA genotype (57.4%), was significant versus for the rest of the cohort (42.6%). In addition, a significant relationship was found between CYP2C9*1 and drug dose (P>0.021).Conclusion: In this study, samples were characterized by higher frequencies of CYP2C9*1 and VKORC1 G/A, determined as higher warfarin taking doses. The results showed a significant relationship of the VCORC1 and CYP2C9 polymorphisms with warfarin sensitivity and severe side effects. Estimating right doses of warfarin to prescribe can help to reduce the risk of over- or under-anticoagulation and subsequently, the risk of thromboembolism or bleeding. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4748690&blobtype=pdf |
| ISSN | 20083009 |
| Journal | International Journal of Hematology-Oncology and Stem Cell Research [Int J Hematol Oncol Stem Cell Res] |
| Volume Number | 9 |
| PubMed Central reference number | PMC4748690 |
| Issue Number | 4 |
| PubMed reference number | 26865929 |
| e-ISSN | 20082207 |
| Language | English |
| Publisher | Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center |
| Publisher Date | 2015-10-01 |
| Publisher Place | Tehran, Iran |
| Access Restriction | Open |
| Rights License | This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright : © International Journal of Hematology-Oncology and Stem Cell Research & Tehran University of Medical Sciences |
| Subject Keyword | CYP2C9 and VKORC1 polymorphisms Polymerase Change Reaction Warfarin dose requirements |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology Transplantation Oncology |
